Pre-and postsynaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis

Dominique Debanne (1) , Oussama El Far (1)

1 UNIS - Inserm U1072 - Unité de Neurobiologie des canaux Ioniques et de la Synapse

This scientific commentary refers to ‘LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory’, by Petit-Pedrol et al. (doi:10.1093/brain/awy253).

Keywords: LGI1; Antibodies; Limbic encephalitis

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology

Dominique Debanne, Oussama El Far. Pre-and postsynaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis. Brain - A Journal of Neurology , 2018. ⟨hal-01963409⟩