Plasticity of intrinsic neuronal excitability

Dominique Debanne (1) , Yanis Inglebert (2) , Michaël Russier (1)

1 UNIS - Inserm U1072 - Unité de Neurobiologie des canaux Ioniques et de la Synapse
2 INSERM - Institut National de la Santé et de la Recherche Médicale

Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.

Keywords: Synaptic Structure; Voltage amplitude

Domains: Neurobiology; Neurons and Cognition [q-bio.NC]

Dominique Debanne, Yanis Inglebert, Michaël Russier. Plasticity of intrinsic neuronal excitability. Current Opinion in Neurobiology, 2019, 54, pp.73-82. ⟨10.1016/j.conb.2018.09.001⟩. ⟨hal-01963474⟩