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Journal Articles Current Opinion in Neurobiology Year : 2019

Plasticity of intrinsic neuronal excitability


Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons. Activation of synaptic glutamate receptors initiates long-lasting changes in neuronal excitability at presynaptic and postsynaptic side. As synaptic plasticity, intrinsic plasticity is bi-directional and expresses a certain level of input-specificity or cell-specificity. We discuss here the nature of the learning rules shared by intrinsic and synaptic plasticity and the impact of intrinsic plasticity on temporal processing.
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hal-01963474 , version 1 (21-12-2018)





Dominique Debanne, Yanis Inglebert, Michaël Russier. Plasticity of intrinsic neuronal excitability. Current Opinion in Neurobiology, 2019, 54, pp.73-82. ⟨10.1016/j.conb.2018.09.001⟩. ⟨hal-01963474⟩
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