Journal articles
Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice
Abstract : The GluA1 subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) plays a crucial, but highly selective, role in cognitive function. Here we analyzed AMPAR expression, AMPAR distribution and spatial learning in mice (Gria1 R/R), expressing the "trafficking compromised" GluA1(Q600R) point mutation. Our analysis revealed somatic accumulation and reduction of GluA1(Q600R) and GluA2, but only slightly reduced CA1 synaptic localization in hippocampi of adult Gria1 R/R mice. These immunohistological changes were accompanied by a strong reduction of somatic AMPAR currents in CA1, and a reduction of plasticity (short-term and long-term potentiation, STP and LTP, respectively) in the CA1 subfield following tetanic and theta-burst stimulation. Nevertheless, spatial reference memory acquisition in the Morris water-maze and on an appetitive Y-maze task was unaffected in Gria1 R/R mice. In contrast, spatial working/short-term memory during both spontaneous and rewarded alternation tasks was dramatically impaired. These findings identify the GluA1(Q600R) mutation as a loss of function mutation that provides independent evidence for the selective role of GluA1 in the expression of short-term memory.
Cited literature [53 references]
https://hal-amu.archives-ouvertes.fr/hal-01963842
Contributor : Fanny Pra <>
Submitted on : Friday, December 21, 2018 - 4:03:45 PM
Last modification on : Tuesday, February 4, 2020 - 10:00:04 AM
Long-term archiving on: : Friday, March 22, 2019 - 6:37:14 PM
Contributor : Fanny Pra <>
Submitted on : Friday, December 21, 2018 - 4:03:45 PM
Last modification on : Tuesday, February 4, 2020 - 10:00:04 AM
Long-term archiving on: : Friday, March 22, 2019 - 6:37:14 PM
File
Bannerman et al, 2018.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License