HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Survenue de symptômes tardifs après un test de provocation par la méthacholine

Abstract : There are few prospective studies available on the development of delayed symptoms following challenge tests with methacholine (MCT) at the currently recommended doses. The objective of this study was to describe the nature and frequency of respiratory symptoms suggestive of bronchospasm developing within 24 hours after a MCT. The study was offered to adult patients who underwent MCT seen consecutively between June and October 2015. Following the test, a questionnaire adapted from the GINA asthma control questionnaire bearing on diurnal and nocturnal symptoms (cough, dyspnoea, wheeze and tightness), was delivered to the patient and the replies collected by telephone 24 hours later. Of the 101 patients included (initial FEV1 2.82 ± 0.79 L), 46 (46 %) were MCT+ and 55 (54 %) MCT−. Among the MCT−, 4 (7 %) presented with immediate symptoms (S+) and 4 (7 %) with delayed symptoms. Among the MCT+ patients, 36 (78 %) presented with immediate symptoms (P < 0.001 compared with the MCT− patients), and 39 (85 %) with delayed symptoms (P < 0.001 compared with the MCT− patients). Delayed symptoms developed with a mean of 5 h 30 after the provocation test. Immediate and delayed symptoms were more frequent in subjects having significant non-specific bronchial hyper-reactivity. Informing patients of the risk of developing delayed symptoms seems useful and allows optimization of their management after a MCT.
Complete list of metadata

Cited literature [12 references]  Display  Hide  Download

Contributor : Isabelle Combe Connect in order to contact the contributor
Submitted on : Friday, April 12, 2019 - 5:06:44 PM
Last modification on : Tuesday, April 19, 2022 - 10:15:38 AM


Publication funded by an institution




E. Cabon, F. Rey, D. Tissier-Ducamp, M.J. del Volgo, S. Delliaux, et al.. Survenue de symptômes tardifs après un test de provocation par la méthacholine. Revue des Maladies Respiratoires, Elsevier Masson, 2018, 35 (3), pp.249-255. ⟨10.1016/j.rmr.2017.09.006⟩. ⟨hal-02006477⟩



Record views


Files downloads