IL-16 is critical for Tropheryma whipplei replication in Whipple's disease. - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2005

IL-16 is critical for Tropheryma whipplei replication in Whipple's disease.

Résumé

Whipple's disease (WD) is a rare systemic disease caused by Tropheryma whipplei. We showed that T. whipplei was eliminated by human monocytes but replicated in monocyte-derived macrophages (Mphi) by inducing an original activation program. Two different host molecules were found to be key elements for this specific pattern. Thioredoxin, through its overexpression in infected monocytes, was involved in bacterial killing because adding thioredoxin to infected Mphi inhibited bacterial replication. IL-16, which was up-regulated in Mphi, enabled T. whipplei to replicate in monocytes and increased bacterial replication in Mphi. In addition, anti-IL-16 Abs abolished T. whipplei replication in Mphi. IL-16 down-modulated the expression of thioredoxin and up-regulated that of IL-16 and proapoptotic genes. In patients with WD, T. whipplei replication was higher than in healthy subjects and was related to high levels of circulating IL-16. Both events were corrected in patients who successfully responded to antibiotics treatment. This role of IL-16 was not reported previously and gives an insight into the understanding of WD pathophysiology.
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Dates et versions

hal-02025871 , version 1 (19-02-2019)

Identifiants

  • HAL Id : hal-02025871 , version 1
  • PUBMED : 16177102

Citer

Benoit Desnues, Didier Raoult, Jean-Louis Mege. IL-16 is critical for Tropheryma whipplei replication in Whipple's disease.. Journal of Immunology, 2005, 175 (7), pp.4575-82. ⟨hal-02025871⟩

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