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Whipple Disease: Intestinal Infiltrating Cells Exhibit a Transcriptional Pattern of M2/Alternatively Activated Macrophages

Abstract : Whipple disease (WD) is a rare systemic disease caused by Tropheryma whipplei and is characterized by the presence of foamy macrophages with periodic acid-Schiff-positive inclusions in tissues such as lamina propria. For the first time, we report the gene-expression profile of macrophages in intestinal lesions from a patient with WD. Microarray and real-time polymerase chain reaction revealed that genes encoding CCL18, cathepsins, scavenger receptor, interleukin-10, and lipid metabolites were up-regulated in intestinal lesions. This transcriptional pattern corresponds to that of M2/alternatively activated macrophages. Our results suggest that the T helper 2 response in the intestinal environment may account for the pathophysiological properties of WD.
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https://hal-amu.archives-ouvertes.fr/hal-02025872
Contributor : Benoit Desnues <>
Submitted on : Tuesday, February 19, 2019 - 9:56:24 PM
Last modification on : Monday, February 17, 2020 - 9:45:26 AM

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Benoit Desnues, Hubert Lepidi, Didier Raoult, Jean-Louis Mege. Whipple Disease: Intestinal Infiltrating Cells Exhibit a Transcriptional Pattern of M2/Alternatively Activated Macrophages. Journal of Infectious Diseases, Oxford University Press (OUP), 2005, 192 (9), pp.1642-1646. ⟨10.1086/491745⟩. ⟨hal-02025872⟩

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