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Meta-Analysis Reveals the Association Between Male Occupational Exposure to Solvents and Impairment of Semen Parameters

Abstract : Objectives: Solvent exposure is among the most common occupational exposures to chemical toxicants; data about the impact of such exposure on semen parameters are contradictory. We conducted the first meta-analysis to evaluate the risk of alteration in semen parameters related to occupational exposure to solvents. Methods: From the PubMed database, we selected studies analyzing the semen of subjects occupationally exposed to solvents, compared with unexposed controls. The meta-analysis was performed on the various semen parameters analyzed in both populations. Results: Seven studies were included in the study. The meta-analysis revealed a significant decrease in ejaculate volume [standardized mean difference (SMD) ¼ À0.35 (À0.63 to À0.07)] and sperm concentration [SMD ¼ À0.36 (À0.64 to À0.08)] in workers exposed to solvents compared with unexposed controls. Conclusion: Our results highlight the importance of preventing reprotoxic risks to male fertility in the workplace.
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Submitted on : Thursday, February 21, 2019 - 4:09:37 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:17 PM
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Oana Ianos, Irène Sari-Minodier, Virginie Villes, Marie-Pascale Lehucher-Michel, Anderson Loundou, et al.. Meta-Analysis Reveals the Association Between Male Occupational Exposure to Solvents and Impairment of Semen Parameters. Journal of Occupational and Environmental Medicine, Lippincott, Williams & Wilkins, 2018, 60 (10), pp.e533-e542. ⟨10.1097/JOM.0000000000001422⟩. ⟨hal-02044732⟩

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