HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Longitudinal study of functional brain network reorganization in clinically isolated syndrome

Abstract : Background: There is a lack of longitudinal studies exploring the topological organization of functional brain networks at the early stages of multiple sclerosis (MS). Objective: This study aims to assess potential brain functional reorganization at rest in patients with CIS (PwCIS) after 1 year of evolution and to characterize the dynamics of functional brain networks at the early stage of the disease. Methods: We prospectively included 41 PwCIS and 19 matched healthy controls (HCs). They were scanned at baseline and after 1 year. Using graph theory, topological metrics were calculated for each region. Hub disruption index was computed for each metric. Results: Hub disruption indexes of degree and betweenness centrality were negative at baseline in patients (p < 0.05), suggesting brain reorganization. After 1 year, hub disruption indexes for degree and betweenness centrality were still negative (p < 0.00001), but such reorganization appeared more pronounced than at baseline. Different brain regions were driving these alterations. No global efficiency differences were observed between PwCIS and HCs either at baseline or at 1 year. Conclusion: Dynamic changes in functional brain networks appear at the early stages of MS and are associated with the maintenance of normal global efficiency in the brain, suggesting a compensatory effect.
Document type :
Journal articles
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-02059512
Contributor : Jean-Philippe Ranjeva Connect in order to contact the contributor
Submitted on : Monday, April 25, 2022 - 5:19:36 PM
Last modification on : Tuesday, April 26, 2022 - 8:26:31 AM

Identifiers

Collections

Citation

Ismail Koubiyr, Mathilde Deloire, Pierre Besson, Pierrick Coupé, Cécile Dulau, et al.. Longitudinal study of functional brain network reorganization in clinically isolated syndrome. Multiple Sclerosis Journal, SAGE Publications, 2018, 26 (2), pp.135245851881310. ⟨10.1177/1352458518813108⟩. ⟨hal-02059512⟩

Share

Metrics

Record views

54

Files downloads

3