Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives - Archive ouverte HAL Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2003

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

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Abstract

We describe the synthesis and the antiviral evaluation of novel alpha and beta dideoxynucleoside derivatives in which the base has been replaced by a 3-hydroxy-2-methylpyridin-4-one. The syntheses were successfully achieved by the use of the standard Vorbrüggen coupling conditions. Moderate activity of these compounds were found on herpes simplex virus (HSV) type 1 and type 2.

Dates and versions

hal-02061650 , version 1 (08-03-2019)

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Karine Barral, Robert Hider, Jan Balzarini, Johan Neyts, Erik de Clercq, et al.. Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives. Bioorganic and Medicinal Chemistry Letters, 2003, 13 (24), pp.4371-4374. ⟨10.1016/j.bmcl.2003.09.033⟩. ⟨hal-02061650⟩
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