Dynamic Reconfiguration of Visuomotor-Related Functional Connectivity Networks

Abstract : Cognitive functions arise from the coordination of large-scale brain networks. However, the principles governing interareal functional connectivity dynamics (FCD) remain elusive. Here, we tested the hypothesis that human executive functions arise from the dynamic interplay of multiple networks. To do so, we investigated FCD mediating a key executing function, known as arbitrary visuomotor mapping, using brain connectivity analyses of high-gamma activity recorded using MEG and intracranial EEG. Visuomotor mapping was found to arise from the dynamic interplay of three partly overlapping cortico-cortical and cortico-subcortical functional connectivity (FC) networks. First, visual and parietal regions coordinated with sensorimotor and premotor areas. Second, the dorsal frontoparietal circuit together with the sensorimotor and associative frontostriatal networks took the lead. Finally, cortico-cortical interhemispheric coordination among bilateral sensorimotor regions coupled with the left frontoparietal network and visual areas. We suggest that these networks reflect the processing of visual information, the emergence of visuomotor plans, and the processing of somatosensory reaffer-ence or action's outcomes, respectively. We thus demonstrated that visuomotor integration resides in the dynamic reconfiguration of multiple cortico-cortical and cortico-subcortical FC networks. More generally, we showed that visuomotor-related FC is nonstationary and displays switching dynamics and areal flexibility over timescales relevant for task performance. In addition, visuomotor-related FC is characterized by sparse connectivity with density 10%. To conclude, our results elucidate the relation between dynamic network reconfiguration and executive functions over short timescales and provide a candidate entry point toward a better understanding of cognitive architectures.
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Contributor : Andrea Brovelli <>
Submitted on : Tuesday, April 2, 2019 - 5:48:02 PM
Last modification on : Friday, April 12, 2019 - 1:31:00 AM

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Andrea Brovelli, Jean-Michel Badier, Francesca Bonini, Fabrice Bartolomei, Xolivier Coulon, et al.. Dynamic Reconfiguration of Visuomotor-Related Functional Connectivity Networks. Journal of Neuroscience, Society for Neuroscience, 2017, ⟨10.1523/JNEUROSCI.1672-16.2016⟩. ⟨hal-02088316⟩

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