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Effect of Foods and beta-Cyclodextrin on the Bioaccessibility and the Uptake by Caco-2 Cells of Hydroxytyrosol from Either a Pure Standard or Alperujo

Abstract : Hydroxytyrosol bioaccessibility and absorption by the intestinal cells were studied using an in vitro digestion model and Caco-2 TC7 monolayers cells in culture in the presence and absence of beta-cyclodextrin and foods. Hydroxytyrosol was either provided as a pure standard or in an alperujo powder. The presence of foods significantly decreased hydroxytyrosol bioaccessibility and absorption (-20 and -10%, respectively), while beta-cyclodextrin had no effect. Moreover, the presence of other compounds from alperujo in the intestinal compartment reduced hydroxytyrosol absorption by Caco-2 cells compared to pure standard (-60%). The final bioavailability of hydroxytyrosol, defined as its quantity at the basolateral side of cultured cell monolayers compared to the initial amount in the test meal, was 6.9 +/- 0.4, 31.1 +/- 1.1, and 40.9 +/- 1.5% when hydroxytyrosol was from alperujo or a standard administered with or without food, respectively. Our results show that conversely to foods, beta-cyclodextrin does not alter hydroxytyrosol bioavailability.
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https://hal-amu.archives-ouvertes.fr/hal-02091257
Contributor : Annick Prémilleux <>
Submitted on : Friday, April 5, 2019 - 3:08:58 PM
Last modification on : Friday, June 26, 2020 - 11:04:03 AM

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Aurelia Malapert, Valerie Tomao, Olivier Dangles, Emmanuelle Reboul. Effect of Foods and beta-Cyclodextrin on the Bioaccessibility and the Uptake by Caco-2 Cells of Hydroxytyrosol from Either a Pure Standard or Alperujo. Journal of Agricultural and Food Chemistry, 2018, 66 (18), pp.4614-4620. ⟨10.1021/acs.jafc.8b00556⟩. ⟨hal-02091257⟩

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