Skip to Main content Skip to Navigation
Journal articles

A pH-driven ring translocation switch against cancer cells

Qian Cheng 1 Hang Yin 2 Roselyne Rosas 3 Didier Gigmes 4 Olivier Ouari 4 Ruibing Wang 2 Anthony Kermagoret 4 David Bardelang 4
1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
2 Institute of Chinese Medical Sciences - State Key Laboratory of Quality Research in Chinese Medicine Taipa, Macau SAR,
3 FRSCM - Fédération des Sciences Chimiques de Marseille
4 ICR - Institut de Chimie Radicalaire
Abstract : A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 10(2) cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.
Document type :
Journal articles
Complete list of metadata
https://hal-amu.archives-ouvertes.fr/hal-02091869
Contributor : Didier Gigmes Connect in order to contact the contributor
Submitted on : Saturday, April 6, 2019 - 5:16:23 PM
Last modification on : Tuesday, January 4, 2022 - 5:05:23 AM

Identifiers

Collections

UNIV-AMU | CNRS | EC-MARSEILLE | INC-CNRS

Citation

Qian Cheng, Hang Yin, Roselyne Rosas, Didier Gigmes, Olivier Ouari, et al.. A pH-driven ring translocation switch against cancer cells. Chemical Communications, Royal Society of Chemistry, 2018, 54 (98), pp.13825--13828. ⟨10.1039/c8cc08681h⟩. ⟨hal-02091869⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Les métriques sont temporairement indisponibles