Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2018

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation

Résumé

By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, lab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 mu M against TK+ and TK- VZV and without measurable cell-growth inhibition. (C) 2018 Elsevier Masson SAS. All rights reserved.

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Chimie
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Dates et versions

hal-02091894 , version 1 (06-04-2019)

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Citer

Hanane Kaoukabi, Youssef Kabri, Christophe Curti, Moha Taourirte, Juan C. Rodriguez-Ubis, et al.. Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation. European Journal of Medicinal Chemistry, 2018, 155, pp.772--781. ⟨10.1016/j.ejmech.2018.06.028⟩. ⟨hal-02091894⟩
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