Skip to Main content Skip to Navigation
Journal articles

First TDAE Reactivity Using Benzonitrile Derivatives as Substrates and Its Application to the Synthesis of 3-Substituted Isochroman-1-ones

Abstract : The first TDAE-initiated reaction between benzonitrile derivatives as substrates and substituted benzaldehydes to form substituted hydroxyethylbenzonitrile derivatives is reported. The 2-hydroxyethyl benzonitrile derivatives thus formed were good candidates for one-pot lactonization in a mixture of hydrochloric acid and methanol at 70 degrees C over five hours. These reactions furnished the corresponding 3-substituted isochroman-1-one derivatives in good yields.
Document type :
Journal articles
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-02091895
Contributor : Didier Gigmes <>
Submitted on : Saturday, April 6, 2019 - 5:17:23 PM
Last modification on : Sunday, April 7, 2019 - 1:22:51 AM

Identifiers

Collections

Citation

Omar Khoumeri, Thierry Terme, Patrice Vanelle. First TDAE Reactivity Using Benzonitrile Derivatives as Substrates and Its Application to the Synthesis of 3-Substituted Isochroman-1-ones. Synthesis-Stuttgart, 2018, 50 (13), pp.2617--2623. ⟨10.1055/s-0036-1591570⟩. ⟨hal-02091895⟩

Share

Metrics

Record views

46