First TDAE Reactivity Using Benzonitrile Derivatives as Substrates and Its Application to the Synthesis of 3-Substituted Isochroman-1-ones

Omar Khoumeri; Thierry Terme; Patrice Vanelle

doi:10.1055/s-0036-1591570

Journal articles

First TDAE Reactivity Using Benzonitrile Derivatives as Substrates and Its Application to the Synthesis of 3-Substituted Isochroman-1-ones

Omar Khoumeri ¹ Thierry Terme ¹ Patrice Vanelle ¹

Abstract : The first TDAE-initiated reaction between benzonitrile derivatives as substrates and substituted benzaldehydes to form substituted hydroxyethylbenzonitrile derivatives is reported. The 2-hydroxyethyl benzonitrile derivatives thus formed were good candidates for one-pot lactonization in a mixture of hydrochloric acid and methanol at 70 degrees C over five hours. These reactions furnished the corresponding 3-substituted isochroman-1-one derivatives in good yields.

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Journal articles

Domain :

Chemical Sciences

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https://hal-amu.archives-ouvertes.fr/hal-02091895
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Submitted on : Saturday, April 6, 2019 - 5:17:23 PM
Last modification on : Sunday, April 7, 2019 - 1:22:51 AM

First TDAE Reactivity Using Benzonitrile Derivatives as Substrates and Its Application to the Synthesis of 3-Substituted Isochroman-1-ones

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First TDAE Reactivity Using Benzonitrile Derivatives as Substrates and Its Application to the Synthesis of 3-Substituted Isochroman-1-ones

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