Insights into the Crystallization and Structural Evolution of Glycine Dihydrate by In Situ Solid-State NMR Spectroscopy

Paolo Cerreia Vioglio (1) , Giulia Mollica (1) , Marie Juramy (1) , Colan E. Hughes (2) , P. Andrew Williams (2) , Fabio Ziarelli (3) , Stephane Viel (1) , Pierre Thureau (1) , Kenneth D. M. Harris (2)

1 ICR - Institut de Chimie Radicalaire
2 School of Chemistry [Cardiff]
3 FRSCM - Fédération des Sciences Chimiques de Marseille

In situ solid-state NMR spectroscopy is exploited to monitor the structural evolution of a glycine/water glass phase formed on flash cooling an aqueous solution of glycine, with a range of modern solid-state NMR methods applied to elucidate structural properties of the solid phases present. The glycine/water glass is shown to crystallize into an intermediate phase, which then transforms to the beta polymorph of glycine. Our in situ NMR results fully corroborate the identity of the intermediate crystalline phase as glycine dihydrate, which was first proposed only very recently.

Keywords: crystallization; glycine; polymorphism; solid-state NMR spectroscopy; structural transformation

Domains: Chemical Sciences

Paolo Cerreia Vioglio, Giulia Mollica, Marie Juramy, Colan E. Hughes, P. Andrew Williams, et al.. Insights into the Crystallization and Structural Evolution of Glycine Dihydrate by In Situ Solid-State NMR Spectroscopy. Angewandte Chemie International Edition, 2018, 57 (22), pp.6619--6623. ⟨10.1002/anie.201801114⟩. ⟨hal-02091904⟩