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Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[n]uril (n=7, 8)

Hang Yin 1 Qiaoxian Huang 1 Wenwen Zhao 1 David Bardelang 2 Didier Siri 2 Xiuping Chen 1 Simon M. Y. Lee 3 Ruibing Wang 1
1 Institute of Chinese Medical Sciences - State Key Laboratory of Quality Research in Chinese Medicine Taipa, Macau SAR,
2 ICR - Institut de Chimie Radicalaire
3 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
Abstract : This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.
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https://hal-amu.archives-ouvertes.fr/hal-02091914
Contributor : Didier Gigmes Connect in order to contact the contributor
Submitted on : Saturday, April 6, 2019 - 5:18:08 PM
Last modification on : Friday, October 22, 2021 - 3:38:16 AM

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Hang Yin, Qiaoxian Huang, Wenwen Zhao, David Bardelang, Didier Siri, et al.. Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[n]uril (n=7, 8). Journal of Organic Chemistry, American Chemical Society, 2018, 83 (8), pp.4882--4887. ⟨10.1021/acs.joc.8b00543⟩. ⟨hal-02091914⟩

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