Rapid synthesis of new 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazole as potential antibacterial drugs through one-pot cyclization and Suzuki-Miyaura coupling

Fanny Mathias (1) , Maxime D. Crozet (1) , Youssef Kabri (1) , Patrice Vanelle (1)

1 ICR - Institut de Chimie Radicalaire

Original 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazoles were prepared by reacting 1-(2,5-dibromo-4-nitro-1H-imidazol-1-yl)propan-2-ol and various arylboronic acids through one-pot cyclization and Suzuki-Miyaura reactions under microwave irradiation. [GRAPHICS] .

Domaines: Chimie

Fanny Mathias, Maxime D. Crozet, Youssef Kabri, Patrice Vanelle. Rapid synthesis of new 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazole as potential antibacterial drugs through one-pot cyclization and Suzuki-Miyaura coupling. Synthetic Communications, 2018, 48 (10), pp.1213--1219. ⟨10.1080/00397911.2018.1439177⟩. ⟨hal-02091930⟩