Preparation of LDA. An oven-dried 2-necked round-bottomed (5 anhydrous and degassed i Pr 2 NH (0.12 mL) and THF (1 mL). The flask was cooled in a liquid N 2 and EtOAc bath, 600 MHz, TCE-d 2 ): 7.73 (s, 2H), 7.71 (m, 2H), 7.67(m, 2H), 7.57(s, 2H), 7,25 (m, 4H), vol.2 ,
, 2 mg, 0.0075 mmol) was dissolved in 0.5 mL of anhydrous and degassed THF-d 8 inside glovebox. Thereto was added 40 uL of freshly prepared LDA solution (0.5 M) via a microsyringe. A dark solution was obtained and transferred to a sealed NMR tube; then NMR spectra were collected. UV?vis ? max (THF) nm: 600, 400. 1 H NMR (400 MHz, UV?vis ? max (THF) nm: 600, 500, 370. 1 H NMR (600 MHz, THF-d 8 ): 8.27?8.23 (m, 2H), 7.99 (d, J = 8.4, 2H), 7.90 (s, 2H), 7.49?7.46 (m, 2H), vol.7
Compound 5 (3.5 mg, 0.0082 mmol) was dissolved in 0.5 mL of anhydrous and degassed THF-d 8 inside glovebox. Thereto was added 40uL of freshly prepared LDA solution (0.5 M) via a microsyringe. An olive green solution was obtained and transferred to a sealed NMR tube; then, NMR spectra were collected. UV?vis ? max (THF) nm: 680, 590, 455. 1 H NMR (600 MHz, THF-d 8 ): 7.52 (dd, J = 7.5, 1.2 Hz, 2H), 7.48 (s, 2H), 7.20 (d, J = 7.6 Hz, 2H), 6.93 (s, 2H), 6.78 (td, CDCl, vol.8, issue.9 ,
, Thereto was added t-BuOK in THF-d 8 (345 uL, 0.023 mmol). A reddish brown solution was obtained and transferred to a sealed NMR tube, mmol) was suspended in 0.3 mL of anhydrous and degassed THF-d 8 inside glovebox, p.600
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