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Conformational response to charge clustering in synthetic intrinsically disordered proteins

Giulia Tedeschi Edoardo Salladini 1 Carlo Santambrogio Rita Grandori Sonia Longhi 1 Stefania Brocca
1 AFMB - Architecture et fonction des macromolécules biologiques
Abstract : Recent theoretical and computational studies have shown that the charge content and, most importantly, the linear distribution of opposite charges are major determinants of conformational properties of intrinsically disordered proteins (IDPs). Charge segregation in a sequence can be measured through κ, which represents a normalized measure of charge asymmetry. A strong inverse correlation between κ and radius of gyration has been previously demonstrated for two independent sets of permutated IDP sequences.
Keywords : Charge distribution Proline content Compaction index Compaction responsiveness to κ IDPs Small-angle X-ray scattering
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https://hal-amu.archives-ouvertes.fr/hal-02094553
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Submitted on : Tuesday, April 9, 2019 - 5:03:35 PM
Last modification on : Friday, December 4, 2020 - 3:09:35 AM

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Giulia Tedeschi, Edoardo Salladini, Carlo Santambrogio, Rita Grandori, Sonia Longhi, et al.. Conformational response to charge clustering in synthetic intrinsically disordered proteins. Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 2018, 1862 (10), pp.2204-2214. ⟨10.1016/j.bbagen.2018.07.011⟩. ⟨hal-02094553⟩

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