The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA, Nature, vol.468, pp.67-71, 2010. ,
CRISPR provides acquired resistance against viruses in prokaryotes, Science, vol.315, pp.1709-1712, 2007. ,
Small CRISPR RNAs guide antiviral defense in prokaryotes, Science, vol.321, pp.960-964, 2008. ,
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity, Science, vol.337, pp.816-821, 2012. ,
Genome engineering using the CRISPR-Cas9 system, Nat. Protoc, vol.8, pp.2281-2308, 2013. ,
Phage response to CRISPR-encoded resistance in Streptococcus thermophilus, J. Bacteriol, vol.190, pp.1390-1400, 2008. ,
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system, Nature, vol.493, pp.429-432, 2013. ,
Disabling Cas9 by an anti-CRISPR DNA mimic, Sci. Adv, vol.3, p.1701620, 2017. ,
Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins, Nature, vol.526, pp.136-139, 2015. ,
Naturally occurring off-switches for CRISPR-Cas9, Cell, vol.167, pp.1-10, 2016. ,
A new group of phage anti-CRISPR genes inhibits the type I-E CRISPRCas system of Pseudomonas aeruginosa, vol.5, pp.896-910, 2014. ,
Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species, Nat. Microbiol, vol.1, p.16085, 2016. ,
Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity, Nat. Microbiol, vol.3, pp.461-469, 2018. ,
Structure reveals mechanisms of viral suppressors that intercept a CRISPR RNA-guided surveillance complex, Cell, vol.169, p.11, 2017. ,
The solution structure of an anti-CRISPR protein, Nat. Commun, vol.7, p.13134, 2016. ,
A broad-spectrum inhibitor of CRISPR-Cas9, Cell, vol.170, p.15, 2017. ,
Cryo-EM Structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex, Cell, vol.171, pp.414-426, 2017. ,
Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures, Cell Res, vol.27, pp.853-864, 2017. ,
Structural basis of Cas3 inhibition by the bacteriophage protein AcrF3, Nat. Struct. Mol. Biol, vol.23, pp.868-870, 2016. ,
Crystal structure of an anti-CRISPR protein, AcrIIA1, Nucleic Acids Res, vol.46, pp.485-492, 2017. ,
An updated evolutionary classification of CRISPR-Cas systems, Nat. Rev. Microbiol, vol.13, pp.722-736, 2015. ,
SnapShot: class 2 CRISPR-Cas systems, Cell, vol.168, p.1, 2017. ,
Anti-CRISPR: discovery, mechanism and function, Nat. Rev. Microbiol, vol.16, pp.12-17, 2018. ,
Inhibition of CRISPR-Cas9 with bacteriophage proteins, Cell, vol.168, p.10, 2017. ,
An anti-CRISPR from a virulent streptococcal phage inhibits Streptococcus pyogenes Cas9, Nat. Microbiol, vol.2, pp.1374-1380, 2017. ,
Multiplex genome engineering using CRISPR/Cas system, Science, vol.339, pp.819-824, 2013. ,
Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein, Nature, vol.546, pp.436-439, 2017. ,
Inhibition mechanism of an anti-CRISPR suppressor AcrIIA4 targeting SpyCas9, Mol. Cell, vol.67, p.5, 2017. ,
Detecting natural adaptation of the Streptococcus thermophilus CRISPR-Cas systems in research and classroom settings, Nat. Protoc, vol.12, pp.547-565, 2017. ,
Global survey and genome exploration of bacteriophages infecting the lactic acid bacterium Streptococcus thermophilus, Front. Microbiol, vol.8, p.1754, 2017. ,
Adaptation in bacterial CRISPR-Cas immunity can be driven by defective phages, Nat. Commun, vol.5, p.4399, 2014. ,
Programming native CRISPR arrays for the generation of targeted immunity, vol.7, pp.202-00216, 2016. ,
Two groups of bacteriophages infecting Streptococcus thermophilus can be distinguished on the basis of mode of packaging and genetic determinants for major structural proteins, Appl. Env. Microbiol, vol.63, pp.3246-3253, 1997. ,
Identification and analysis of a novel group of bacteriophages infecting the lactic acid bacterium Streptococcus thermophilus, Appl. Env. Microbiol, vol.82, pp.5153-5165, 2016. ,
Novel variants of Streptococcus thermophilus bacteriophages are indicative of genetic recombination among phages from different bacterial species, Appl. Env. Microbiol, vol.83, pp.2748-2764, 2017. ,
Dali server: conservation mapping in 3D, Nucleic Acids Res, vol.38, pp.545-549, 2010. ,
Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex, Nucleic Acids Res, vol.40, pp.4158-4167, 2012. ,
Cleavage of phage DNA by the Streptococcus thermophilus CRISPR3-Cas system, PLoS ONE, vol.7, p.40913, 2012. ,
Complete genomic sequence of the lytic bacteriophage DT1 of Streptococcus thermophilus, Virology, vol.255, pp.63-76, 1999. ,
Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome, Mol. Ther, vol.24, pp.636-644, 2016. ,
A rapid and general assay for monitoring endogenous gene modification, Methods Mol. Biol, vol.649, pp.247-256, 2010. ,
Rapid and scalable characterization of CRISPR technologies using an E. coli cell-free transcription-translation system, Mol. Cell, vol.69, pp.146-157, 2018. ,
Ray Meta: scalable de novo metagenome assembly and profiling, Genome Biol, vol.13, p.122, 2012. ,
hmm: new solutions for gene finding, Nucleic Acids Res, vol.26, pp.1107-1115, 1998. ,
ORF-FINDER: a vector for high-throughput gene identification, Gene, vol.282, pp.33-41, 2002. ,
High-frequency transformation, by electroporation, of Lactococcus lactis subsp. cremoris grown with glycine in osmotically stabilized media, Appl Env. Microbiol, vol.55, pp.3119-3123, 1989. ,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res, vol.25, pp.3389-3402, 1997. ,
Basic local alignment search tool, J. Mol. Biol, vol.215, pp.403-410, 1990. ,
Improved detection of helix-turn-helix DNA-binding motifs in protein sequences, Nucleic Acids Res, vol.18, pp.5019-5026, 1990. ,
The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis, Nucleic Acids Res, vol.44, pp.410-415, 2016. ,
JPred4: a protein secondary structure prediction server, Nucleic Acids Res, vol.43, pp.389-394, 2015. ,
Optimization of crystals from nanodrops: crystallization and preliminary crystallographic study of a pheromone-binding protein from the honeybee Apis mellifera L, Acta Crystallogr. D. Biol. Crystallogr, vol.59, pp.919-921, 2003. ,
, Acta Crystallogr. D. Biol. Crystallogr, vol.66, pp.125-132, 2010.
Overview of the CCP4 suite and current developments, Acta Crystallogr. D. Biol. Crystallogr, vol.67, pp.235-242, 2011. ,
The Buccaneer software for automated model building, Acta Crystallogr. D. Biol. Crystallogr, vol.62, pp.1002-1011, 2006. ,
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT, Acta Crystallogr. D. Biol. Crystallogr, vol.60, pp.2210-2221, 2004. ,
Features and development of Coot, Acta Crystallogr. D. Biol. Crystallogr, vol.66, pp.486-501, 2010. ,
A scalable genome-editing-based approach for mapping multiprotein complexes in human cells, Cell Rep, vol.13, pp.621-633, 2015. ,
Engineered CRISPR-Cas9 nucleases with altered PAM specificities, Nature, vol.523, pp.481-485, 2015. ,
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects, Nature, vol.529, pp.290-295, 2016. ,