D. Wever, O. Demetter, P. Mareel, M. Bracke, and M. , Stromal myofibroblasts are drivers of invasive cancer growth, Int J Cancer, vol.123, issue.10, pp.2229-2267, 2008.

J. Leca, S. Martinez, S. Lac, J. Nigri, V. Secq et al., Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness, J Clin Invest, vol.126, issue.11, pp.4140-56, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01408056

M. H. Sherman, R. T. Yu, T. W. Tseng, C. M. Sousa, S. Liu et al., Stromal cues regulate the pancreatic cancer epigenome and metabolome, Proc Natl Acad Sci U S A, vol.114, issue.5, pp.1129-1163, 2017.

A. Miller, C. Nagy, B. Knapp, J. Laengle, E. Ponweiser et al., Exploring metabolic configurations of single cells within complex tissue microenvironments, Cell Metab, vol.26, issue.5, pp.788-800, 2017.

I. L. Romero, A. Mukherjee, H. A. Kenny, L. M. Litchfield, and E. Lengyel, Molecular pathways: trafficking of metabolic resources in the tumor microenvironment, Clin Cancer Res, vol.21, issue.4, pp.680-686, 2015.

Y. Fu, S. Liu, S. Yin, W. Niu, W. Xiong et al., The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy, Oncotarget, vol.8, issue.34, pp.57813-57838, 2017.

P. Danhier, P. Banski, V. L. Payen, D. Grasso, L. Ippolito et al., Cancer metabolism in space and time: beyond the Warburg effect, Biochim Biophys Acta, issue.8, pp.556-72, 2017.

T. Fiaschi, A. Marini, E. Giannoni, M. L. Taddei, P. Gandellini et al., Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay, Cancer Res, vol.72, pp.5130-5170, 2012.

T. Shan, S. Chen, X. Chen, W. R. Lin, W. Li et al., Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism, Oncol Rep, vol.37, issue.4, pp.1971-1980, 2017.

C. M. Sousa, D. E. Biancur, X. Wang, C. J. Halbrook, M. H. Sherman et al., Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion, Nature, vol.536, issue.7617, pp.479-83, 2016.

J. Y. Chen, C. F. Li, C. C. Kuo, K. K. Tsai, M. F. Hou et al., Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression, Breast Cancer Res, vol.16, issue.4, p.410, 2014.

U. E. Martinez-outschoorn, M. P. Lisanti, and F. Sotgia, Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth, Semin Cancer Biol, vol.25, pp.47-60, 2014.

H. Zhao, L. Yang, J. Baddour, A. Achreja, V. Bernard et al., Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism, Elife, vol.5, p.10250, 2016.

H. A. Brauer, L. Makowski, K. A. Hoadley, P. Casbas-hernandez, L. J. Lang et al., Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer, Clin Cancer Res, vol.19, issue.3, pp.571-85, 2013.

L. Yang, A. Achreja, T. L. Yeung, L. S. Mangala, D. Jiang et al., Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironmentregulated cancer cell growth, Cell Metab, vol.24, issue.5, pp.685-700, 2016.

A. Achreja, H. Zhao, L. Yang, T. H. Yun, J. Marini et al., Exo-MFAa 13C metabolic flux analysis framework to dissect tumor microenvironmentsecreted exosome contributions towards cancer cell metabolism, Metab Eng, pp.156-72, 2017.

F. Guillaumond, J. Leca, O. Olivares, M. N. Lavaut, N. Vidal et al., Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma, Proc Natl Acad Sci U S A, vol.110, issue.10, pp.3919-3943, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01460466

B. Faubert, K. Y. Li, L. Cai, C. T. Hensley, J. Kim et al., Lactate metabolism in human lung tumors, Cell, vol.171, issue.2, 2017.

E. Allen, P. Mieville, C. M. Warren, S. Saghafinia, L. Li et al., Metabolic symbiosis enables adaptive resistance to anti-angiogenic therapy that is dependent on mTOR signaling, Cell Rep, vol.15, issue.6, pp.1144-60, 2016.

C. A. Lyssiotis and A. C. Kimmelman, Metabolic interactions in the tumor microenvironment, Trends Cell Biol, vol.27, issue.11, pp.863-75, 2017.

C. Feillet, G. T. Van-der-horst, F. Levi, D. A. Rand, and F. Delaunay, Coupling between the circadian clock and cell cycle oscillators: implication for healthy cells and malignant growth, Front Neurol, vol.6, p.96, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01255098

S. Y. Krishnaiah, G. Wu, B. J. Altman, J. Growe, S. D. Rhoades et al., Clock regulation of metabolites reveals coupling between transcription and metabolism, Cell Metab, vol.25, issue.4, pp.961-74, 2017.

A. Ballesta, P. F. Innominato, R. Dallmann, D. A. Rand, and F. A. Levi, Systems chronotherapeutics, Pharmacol Rev, vol.69, issue.2, pp.161-99, 2017.
URL : https://hal.archives-ouvertes.fr/hal-00780810

C. Commisso, S. M. Davidson, R. G. Soydaner-azeloglu, S. J. Parker, J. J. Kamphorst et al., Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells, Nature, vol.497, issue.7451, pp.633-640, 2013.

S. M. Davidson, J. O. Keibler, M. A. Hou, H. W. Luengo, A. Mayers et al., Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors, Nat Med, vol.23, issue.2, pp.235-276, 2017.

J. J. Kamphorst, M. Nofal, C. Commisso, S. R. Hackett, W. Lu et al., Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein, Cancer Res, vol.75, issue.3, pp.544-53, 2015.

O. Olivares, J. R. Mayers, V. Gouirand, M. E. Torrence, T. Gicquel et al., Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions, Nat Commun, vol.8, p.16031, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01788014

Z. T. Schug, B. Peck, D. T. Jones, Q. Zhang, S. Grosskurth et al., Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress, Cancer Cell, vol.27, issue.1, pp.57-71, 2015.

D. Huang, T. Li, L. Wang, L. Zhang, R. Yan et al., Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress, Cell Res, vol.26, issue.10, pp.1112-1142, 2016.

H. B. Kang, J. Fan, R. Lin, S. Elf, J. Q. Zhao et al., Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling, Mol Cell, vol.59, issue.3, pp.345-58, 2015.

S. Xia, R. Lin, J. L. Zhao, L. Kang, H. B. Pan et al., Prevention of dietary-fatfueled ketogenesis attenuates BRAF V600E tumor growth, Cell Metab, vol.25, issue.2, pp.358-73, 2017.

C. K. Huang, P. H. Chang, W. H. Kuo, C. L. Chen, Y. M. Jeng et al., Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via beta-hydroxybutyrate, Nat Commun, vol.8, p.14706, 2017.

J. B. Spinelli, H. Yoon, A. E. Ringel, S. Jeanfavre, C. B. Clish et al., Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass, Science, vol.358, issue.6365, pp.941-947, 2017.

M. Egeblad, E. S. Nakasone, and Z. Werb, Tumors as organs: complex tissues that interface with the entire organism, Dev Cell, vol.18, issue.6, pp.884-901, 2010.

C. J. Whatcott, C. H. Diep, P. Jiang, A. Watanabe, J. Lobello et al., Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer, Clin Cancer Res, vol.21, issue.15, pp.3561-3569, 2015.

S. Christen, D. Lorendeau, R. Schmieder, D. Broekaert, K. Metzger et al., Breast cancer-derived lung metastases show increased pyruvate carboxylase-dependent anaplerosis, Cell Rep, vol.17, issue.3, pp.837-885, 2016.

J. M. Loo, A. Scherl, A. Nguyen, F. Y. Man, E. Weinberg et al., Extracellular metabolic energetics can promote cancer progression, Cell, vol.160, issue.3, pp.393-406, 2015.

O. G. Mcdonald, X. Li, T. Saunders, R. Tryggvadottir, S. J. Mentch et al., Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis, Nat Genet, vol.49, issue.3, pp.367-76, 2017.

M. Y. Fong, W. Zhou, L. Liu, A. Y. Alontaga, M. Chandra et al., Breastcancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis, Nat Cell Biol, vol.17, issue.2, pp.183-94, 2015.