Journal articles
The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation
Stefan O. Ciurea
Kai Cao
Marcelo Fernadez-Vina
Piyanuch Kongtim
Monzr Al Malki
Ephraim Fuchs
Leo Luznik
Xiao-Jun Huang
Fabio Ciceri
1
Franco Locatelli
2
Franco Aversa
3
Luca Castagna
4, 5, 6
Andrea Bacigalupo
7, 8
Massimo Martelli
Didier Blaise
9, 10
Rupert Handgretinger
Denis-Claude Roy
Paul O'Donnell
Asad Bashey
Hillard M. Lazarus
Karen Ballen
Bipin N. Savani
Mohamad Mohty
11
Arnon Nagler
12
Andrea Bacigalupo 7, 8
Author
Massimo Martelli
Author
Didier Blaise 9, 10
Author
Rupert Handgretinger
Author
1
IRCCS Ospedale San Raffaele [Milan, Italy] (Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele,
Via Olgettina Milano, 60, 20132 Milano. - Italy)
3
Department of Clinical and Experimental Medicine (Italy)
- University of Parma (Str. dell'Università, 12, 43121 Parma PR - Italy)
4
Département d'Hématologie [Marseille] (Marseille - France)
5
Unité de Transplantation et de Thérapie Cellulaire [Marseille] (Marseille - France)
7
Department of Hematology II [Genova, Italy] ( Largo Rosanna Benzi, 10, 16132 Genova. - Italy)
- Ospedale San Martino [Genova, Italy] ( Largo Rosanna Benzi, 10, 16132 Genova. - Italy)
8
Università cattolica del Sacro Cuore [Roma, Italy] (Largo Francesco Vito, 1, 00168 Roma. - Italy)
10
CRCM - Centre de Recherche en Cancérologie de Marseille (27 bd Leï Roure, BP 300059
13273 Marseille Cedex 09 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7258 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1068 (101, rue de Tolbiac, 75013 Paris - France)
- Institut Paoli-Calmettes : UMR7258 (France)
- AMU - Aix Marseille Université : UM105 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
11
CRCNA - Centre de Recherche en Cancérologie Nantes-Angers (France)
- CHU Angers - Centre Hospitalier Universitaire d'Angers (4 rue Larrey - 49933 Angers cedex 9 - France)
- Hôtel-Dieu de Nantes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- Hôpital Laennec (France)
- CNRS - Centre National de la Recherche Scientifique (France)
- Faculté de Médecine d'Angers (Rue Haute de Reculée 49045 Angers - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
12
UPMC - Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (4 place Jussieu - 75005 Paris - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
Abstract : Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.
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https://hal-amu.archives-ouvertes.fr/hal-02143577
Contributor : Ghislain Bidaut <>
Submitted on : Wednesday, May 29, 2019 - 2:48:41 PM
Last modification on : Friday, December 11, 2020 - 3:12:58 AM
Contributor : Ghislain Bidaut <>
Submitted on : Wednesday, May 29, 2019 - 2:48:41 PM
Last modification on : Friday, December 11, 2020 - 3:12:58 AM
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- HAL Id : hal-02143577, version 1
- DOI : 10.1038/s41409-017-0062-8
Citation
Stefan O. Ciurea, Kai Cao, Marcelo Fernadez-Vina, Piyanuch Kongtim, Monzr Al Malki, et al.. The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. Bone Marrow Transplantation, Nature Publishing Group, 2018, 53 (5), pp.521-534. ⟨10.1038/s41409-017-0062-8⟩. ⟨hal-02143577⟩
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