Skip to Main content Skip to Navigation
Journal articles

Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies

Abstract : Despite several clinical trials implemented, no antiviral drug could demonstrate efficacy against Ebola virus. In non-human primates, early initiation of polymerase inhibitors favipiravir and remdesivir improves survival, but whether they could be effective in patients is unknown. Here we analyze the impact of antiviral therapy by using a mathematical model that integrates virological and immunological data of 44 cynomolgus macaques, left untreated or treated with favipiravir. We estimate that favipiravir has a similar to 50% efficacy in blocking viral production, which results in reducing virus growth and cytokine storm while IFN alpha reduces cell susceptibility to infection. Simulating the effect of delayed initiations of treatment, our model predicts survival rates of 60% for favipiravir and 100% for remdesivir when treatment is initiated within 3 and 4 days post infection, respectively. These results improve the understanding of Ebola immuno-pathogenesis and can help optimize antiviral evaluation in future outbreaks.
Document type :
Journal articles
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-02143599
Contributor : Ghislain Bidaut <>
Submitted on : Wednesday, May 29, 2019 - 2:49:45 PM
Last modification on : Wednesday, May 20, 2020 - 3:42:10 PM

Links full text

Identifiers

Collections

Citation

Vincent Madelain, Sylvain Baize, Frederic Jacquot, Stephanie Reynard, Alexandra Fizet, et al.. Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies. Nature Communications, Nature Publishing Group, 2018, 9, ⟨10.1038/s41467-018-06215-z⟩. ⟨hal-02143599⟩

Share

Metrics

Record views

51