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STEEx, a boundary between the world of quiescence and the vegetative cycle

Abstract : Telomere maintenance mechanism is poorly studied in quiescence, a reversible non-proliferative state. We previously described in fission yeast a new mode of repair of telomeres named STEEx, that specifically operates in post-mitotic cells harboring eroded telomeres. This mechanism, promoted by transcription-induced telomeric recombination, prevents cells to exit properly from quiescence, suggesting that STEEx act as an anti-proliferative barrier. Here, we further showed that STEEx are genetically controlled by the Tel1(ATM)- and Rad3(ATR)- dependent DDR pathways. We discussed the possibility that STEEx represent a boundary between quiescence and vegetative cycle.
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https://hal-amu.archives-ouvertes.fr/hal-02143607
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Submitted on : Wednesday, May 29, 2019 - 2:50:05 PM
Last modification on : Thursday, March 12, 2020 - 8:54:08 AM

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Laetitia Maestroni, Vincent Geli, Stephane Coulon. STEEx, a boundary between the world of quiescence and the vegetative cycle. Current Genetics, Springer Verlag, 2018, 64 (4), pp.901-905. ⟨10.1007/s00294-018-0808-x⟩. ⟨hal-02143607⟩

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