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PD-L1 expression and PD-1/PD-L1 inhibitors in breast cancer

Abstract : The development of immune checkpoints inhibitors represents one of the major recent advances in oncology. Monoclonal antibodies directed against the programmed cell death protein 1 (PD-1) or its ligand (PD-L1) provides durable disease control, particularly in melanoma, lung, kidney, bladder and head and neck cancers. The purpose of this review is to synthesize current data on the expression of PD-L1 in breast cancer and on the preliminary clinical results of PD-1/PD-L1 inhibitors in breast cancer patients. In breast cancer, PD-L1 expression is heterogeneous and is generally associated with the presence of tumor-infiltrating lymphocytes as well as the presence of poor-prognosis factors, such as young age, high grade, ER-negativity, PR-negativity, and HER-2 overexpression, high proliferative index, and aggressive molecular subtypes (triple negative, basal-like, HER-2-overexpressing). Its prognostic value remains controversial when assessed with immunohistochemistry, whereas it seems favorable in triple-negative cancers when assessed at the mRNA level. Early clinical trials with PD-1/PD-L1 inhibitors in breast cancer have shown efficacy in terms of tumor response and/or disease control in refractory metastatic breast cancers, notably in the triple-negative subtype. Many trials are currently underway, both in the metastatic and neo-adjuvant setting. A crucial issue is identification of biomarkers predictive of response to PD-1/PD-L1 inhibitors.
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https://hal-amu.archives-ouvertes.fr/hal-02143676
Contributor : Ghislain Bidaut <>
Submitted on : Wednesday, May 29, 2019 - 2:53:10 PM
Last modification on : Wednesday, August 14, 2019 - 4:08:13 PM

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Audrey Monneur, Anthony Goncalves, Francois Bertucci. PD-L1 expression and PD-1/PD-L1 inhibitors in breast cancer. Bulletin du Cancer, John Libbey Eurotext, 2018, 105 (3), pp.261-272. ⟨10.1016/j.bulcan.2017.11.012⟩. ⟨hal-02143676⟩

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