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Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients (ANRS CO13-HEPAVIH)

Abstract : Liver steatosis is common in human immunodeficiency virus (HIV)-hepatitis C virus (HCV)-co-infected patients. Some recent studies have found that cannabis use is negatively associated with insulin resistance in the general population and in HIV-HCV-co-infected patients. Given the causal link between insulin resistance and steatosis, we hypothesized that cannabis use has a positive impact on steatosis. Therefore, we aimed to study whether cannabis use in this population was associated with a reduced risk of steatosis, measured by ultrasound examination. ANRS CO13-HEPAVIH is a French nationwide multicentre cohort of HIV-HCV-co-infected patients. Medical and socio-behavioural data from clinical follow-up visits and annual self-administered questionnaires were prospectively collected. A cross-sectional analysis was conducted using data from the first visit where both ultrasound examination data for steatosis (positive or negative diagnosis) and data on cannabis use were available. A logistic regression model was used to evaluate the association between cannabis use and steatosis. Among study sample patients (n=838), 40.1% had steatosis. Fourteen per cent reported daily cannabis use, 11.7% regular use and 74.7% no use or occasional use (never or sometimes). Daily cannabis use was independently associated with a reduced prevalence of steatosis (adjusted odds ratio [95% CI]=0.64 [0.42;0.99]; P=.046), after adjusting for body mass index, hazardous alcohol consumption and current or lifetime use of lamivudine/zidovudine. Daily cannabis use may be a protective factor against steatosis in HIV-HCV-co-infected patients. These findings confirm the need for a clinical evaluation of cannabis-based pharmacotherapies in this population. Eudract.ema.europa.eu number, DGS050367.
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https://hal-amu.archives-ouvertes.fr/hal-02146848
Contributor : Jean-Charles Dufour Connect in order to contact the contributor
Submitted on : Tuesday, June 4, 2019 - 11:48:15 AM
Last modification on : Wednesday, November 3, 2021 - 5:50:24 AM

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F. Dabis, J. Chas, D. Rey, L. Wittkop, P. Sogni, et al.. Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients (ANRS CO13-HEPAVIH). Journal of Viral Hepatitis, Wiley-Blackwell, 2018, 25 (2), pp.171-179. ⟨10.1111/jvh.12797⟩. ⟨hal-02146848⟩

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