S. Perpoint, S. Roux, C. Degroodt, . Brochier, C. Valour et al.,

L. Berger, Y. N'guyen, D. Lambert, D. Lebrun, I. Kmiec et al.,

M. Fischer, . Partisani, M. Cheneau, . Priester, . Batard et al.,

S. G. Deeks and A. N. Phillips, HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity, BMJ, vol.338, 2009.

M. Smit, K. Brinkman, S. Geerlings, C. Smit, K. Thyagarajan et al., Future challenges for clinical care of an ageing population infected with HIV: a modelling study, Lancet Infect Dis, vol.15, issue.7, p.26070969, 2015.

S. Patterson, A. Cescon, H. Samji, K. Chan, W. Zhang et al., Life expectancy of HIV-positive individuals on combination antiretroviral therapy in Canada, BMC Infect Dis, vol.15, p.274, 2015.

R. A. Legarth, M. G. Ahlstrom, G. Kronborg, C. S. Larsen, C. Pedersen et al., Long-Term Mortality in HIV-Infected Individuals 50 Years or Older: A Nationwide, Population-Based Cohort Study, J Acquir Immune Defic Syndr, vol.71, issue.2, p.26334734, 2016.

K. N. Althoff, K. A. Mcginnis, C. M. Wyatt, M. S. Freiberg, C. Gilbert et al., Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults, Clin Infect Dis, vol.60, issue.4, pp.627-665, 2015.

H. Samji, A. Cescon, R. S. Hogg, S. P. Modur, K. N. Althoff et al., Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada, PLoS One, vol.8, issue.12, p.24367482, 2013.

T. T. Brown and R. B. Qaqish, Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review, AIDS, vol.20, issue.17, p.17086056, 2006.

M. S. Shiels, S. R. Cole, G. D. Kirk, and C. Poole, A meta-analysis of the incidence of non-AIDS cancers in HIVinfected individuals, J Acquir Immune Defic Syndr, vol.52, issue.5, pp.611-633, 2009.

T. T. Brown, K. Tassiopoulos, R. J. Bosch, C. Shikuma, and G. A. Mccomsey, Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy. Diabetes Care, vol.33, p.20664016, 2010.

T. H. Burdo, A. Weiffenbach, S. P. Woods, S. Letendre, R. J. Ellis et al., Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection, AIDS, vol.27, issue.9, p.23435298, 2013.

D. A. Duprez, L. H. Kuller, R. Tracy, J. Otvos, D. A. Cooper et al., Lipoprotein particle subclasses, cardiovascular disease and HIV infection, Atherosclerosis, vol.207, issue.2, p.19515371, 2009.

I. Schafer, H. Hansen, G. Schon, S. Hofels, A. Altiner et al., The influence of age, gender and socio-economic status on multimorbidity patterns in primary care. First results from the multicare cohort study, BMC Health Serv Res, vol.12, p.22471952, 2012.

S. Pathai, H. Bajillan, A. L. Landay, and K. P. High, Is HIV a model of accelerated or accentuated aging?, J Gerontol A Biol Sci Med Sci, vol.69, issue.7, pp.833-875, 2014.

P. Pugliese, L. Cuzin, A. Cabie, I. Poizot-martin, C. Allavena et al., A large French prospective cohort of HIV-infected patients: the Nadis Cohort, HIV Med, vol.10, issue.8, p.19486189, 2009.

I. Levy, Y. Maor, N. Mahroum, L. Olmer, A. Wieder et al., Missed opportunities for earlier diagnosis of HIV in patients who presented with advanced HIV disease: a retrospective cohort study, BMJ Open, vol.6, issue.11, p.5129188, 2016.

S. Mensforth, L. Goodall, N. Bodasing, and J. Coultas, Late diagnosis among our ageing HIV population: a cohort study, J Int AIDS Soc, vol.17, issue.4, p.4225407, 2014.

, Guidelines for treatment of HIV infected adults in Europe, 2017.

V. Joly, C. Burdet, R. Landman, F. Raffi, C. Katlama et al., Promising results of dolutegravir + lamivudine maintenance in ANRS 167 LAMIDOL trial Conference on Retroviruses and Opportunistic Infection, 2017.

C. Katlama, L. Assoumou, M. A. Valantin, C. Soulie, C. Duvivier et al., Maraviroc plus raltegravir failed to maintain virological suppression in HIV-infected patients with lipohypertrophy: results from the ROCnRAL ANRS 157 study, J Antimicrob Chemother, vol.69, issue.6, pp.1648-52, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01917896

V. Reliquet, C. Chirouze, C. Allavena, P. Muret, G. Peytavin et al., Nevirapine-raltegravir combination, an NRTI and PI/r sparing regimen, as maintenance antiretroviral therapy in virologically suppressed HIV-1-infected patients, Antivir Ther, vol.19, issue.1, pp.117-140, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01115499

C. Katlama, J. Reynes, L. Assoumou, M. A. Valantin, L. Beniguel et al., Raltegravir/etravirine as maintenance strategy in HIV-1-infected virologically suppressed individuals aged over 45 years on prior boosted protease inhibitor containing regimen: results at, W48 of the ANRS163-ETRAL study 9th IAS Conference on HIV Science, pp.23-26, 2017.

P. Gantner, L. Cuzin, C. Allavena, A. Cabie, P. Pugliese et al., Efficacy and safety of dolutegravir and rilpivirine dual therapy as a simplification strategy: a cohort study, p.28444816
URL : https://hal.archives-ouvertes.fr/hal-01906302

G. Guaraldi, G. Orlando, S. Zona, M. Menozzi, F. Carli et al., Premature age-related comorbidities among HIV-infected persons compared with the general population, Clin Infect Dis, vol.53, issue.11, pp.1120-1126, 2011.

J. Schouten, F. W. Wit, I. G. Stolte, N. A. Kootstra, M. Van-der-valk et al., Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study, Clin Infect Dis, vol.59, issue.12, pp.1787-97, 2014.

R. A. Van-zoest, F. W. Wit, K. W. Kooij, M. Van-der-valk, J. Schouten et al., Higher Prevalence of Hypertension in HIV-1-Infected Patients on Combination Antiretroviral Therapy Is Associated With Changes in Body Composition and Prior Stavudine Exposure, Clin Infect Dis, vol.63, issue.2, p.27143668, 2016.

S. Serrano-villar, M. J. Perez-elias, F. Dronda, J. L. Casado, A. Moreno et al., Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/ CD8 ratio, PLoS One, vol.9, issue.1, p.24497929, 2014.

H. Collaboration-of-observational, C. A. Sabin, C. J. Smith, A. Monforte, M. Battegay et al., Response to combination antiretroviral therapy: variation by age, AIDS, vol.22, issue.12, p.18614870, 2008.

S. G. Deeks, HIV infection, inflammation, immunosenescence, and aging, Annu Rev Med, vol.62, p.21090961, 2011.

N. I. Wada, L. P. Jacobson, J. B. Margolick, E. C. Breen, B. Macatangay et al., The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation, AIDS, vol.29, issue.4, p.25630041, 2015.

M. Hentzien, M. Drame, C. Allavena, C. Jacomet, M. A. Valantin et al., Impact of Age-related Comorbidities on Five-year Overall Mortality among Elderly HIV-Infected Patients in the Late HAART Era-Role of Chronic Renal Disease, J Nutr Health Aging, vol.20, issue.4, pp.408-422, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01509594

M. A. Steinman and J. T. Hanlon, Managing medications in clinically complex elders, JAMA, vol.304, issue.14, p.20940385, 2010.

M. Greene, M. A. Steinman, I. R. Mcnicholl, V. Valcour, and . Polypharmacy, drug-drug interactions, and potentially inappropriate medications in older adults with human immunodeficiency virus infection, J Am Geriatr Soc, vol.62, issue.3, p.24576251, 2014.

G. Guaraldi and K. Rockwood, Geriatric-HIV medicine is born, Clin Infect Dis, 2017.

H. K. Singh, D. Carmen, T. Freeman, R. Glesby, M. J. Eugenia et al., From One Syndrome to Many: Incorporating Geriatric Consultation into HIV Care

C. Jacomet, P. Berland, M. Guiguet, A. Simon, D. Rey et al., Impact of age on care pathways of people living with HIV followed up in hospital, AIDS Care, vol.29, issue.1, p.27334840, 2016.