Journal articles
Lymph-node metastasis following total laryngectomy and total pharyngolaryngectomy for laryngeal and hypopharyngeal squamous cell carcinoma: Frequency, distribution and risk factors
Abstract : Objectives: To evaluate the prevalence and distribution of lymph-node metastasis after total laryngectomy or total pharyngolaryngectomy. Material and methods: Retrospective single-center series of 136 successive patients undergoing total laryngectomy or total pharyngolaryngectomy with neck dissection for squamous cell carcinoma of the larynx or hypopharynx. Results: The primary site was laryngeal in 110 cases and hypopharyngeal in 26. In 63 patients, surgery was first-line treatment; 73 were operated on for recurrence. The lymph-node metastasis rate, confirmed on histology, was 44.8% regardless of primary site. Hypopharyngeal location was a risk factor for lymph node metastasis (73.1%, P = 0.002) as was the supraglottic subsite (64.3%, P = 0.039). Levels Ha and III were invaded in 28.7% and 25.7% of cases, respectively. Level VIb lymph-node involvement was 23.8% in patients who underwent level VIb neck dissection. Lymph-node recurrence rate was 10.3% in levels II to IV and 13.2% in VIb. Conclusions: Whatever the tumor site, levels Ha and III were most frequently invaded. The high rate of histological involvement of level VIb and of recurrence argues for systematic elective bilateral neck dissection of these territories in some primary sites. (C) 2017 Elsevier Masson SAS. All rights reserved.
https://hal-amu.archives-ouvertes.fr/hal-02146852
Contributor : Jean-Charles Dufour <>
Submitted on : Tuesday, June 4, 2019 - 11:48:28 AM
Last modification on : Wednesday, March 25, 2020 - 2:36:30 PM
Contributor : Jean-Charles Dufour <>
Submitted on : Tuesday, June 4, 2019 - 11:48:28 AM
Last modification on : Wednesday, March 25, 2020 - 2:36:30 PM
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