M. Goldberg, A. Njeh, and E. Uzunoglu, Is pulp inflammation a prerequisite for pulp healing and regeneration?, Mediators Inflammation, p.347649, 2015.

P. R. Cooper, M. J. Holder, and A. J. Smith, Inflammation and regeneration in the dentin-pulp complex: a double-edged sword, J Endod, vol.40, pp.46-51, 2014.

W. Da-rosa, E. Piva, and A. F. Da-silva, Disclosing the physiology of pulp tissue for vital pulp therapy, Int Endod J, vol.51, pp.829-875, 2018.

T. Lawrence, The nuclear factor NF-B pathway in inflammation, Cold Spring Harb Perspect Biol, vol.1, p.1651, 2009.

K. Ley, C. Laudanna, M. I. Cybulsky, and S. Nourshargh, Getting to the site of inflammation: the leukocyte adhesion cascade updated, Nat Rev Immunol, vol.7, pp.678-89, 2007.

K. Murphy, P. Travers, M. Walport, and C. Janeway, Janeway's immunobiology, 2012.

F. Chmilewsky, C. Jeanneau, P. Laurent, and I. About, Pulp fibroblasts synthesize functional complement proteins involved in initiating dentin-pulp regeneration, Am J Pathol, vol.184, pp.1991-2000, 2014.

M. U. Ehrengruber, T. Geiser, and D. A. Deranleau, Activation of human neutrophils by C3a and C5A Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst, FEBS Lett, vol.346, pp.181-185, 1994.

K. Hartmann, B. M. Henz, S. Krüger-krasagakes, J. Köhl, R. Burger et al., C3a and C5a stimulate chemotaxis of human mast cells, Blood, vol.89, pp.2863-70, 1997.

S. Nataf, N. Davoust, R. S. Ames, and S. R. Barnum, Human T cells express the C5a receptor and are chemoattracted to C5a, J Immunol Baltim Md, vol.1950, issue.162, pp.4018-4041, 1999.

D. Ricklin, G. Hajishengallis, K. Yang, and J. D. Lambris, Complement: a key system for immune surveillance and homeostasis, Nat Immunol, vol.11, pp.785-97, 2010.

S. Tomlinson, Complement defense mechanisms, Curr Opin Immunol, vol.5, pp.83-92, 1993.

C. Jeanneau, P. Rufas, C. Rombouts, G. T. Dejou, J. About et al., Can pulp fibroblasts kill cariogenic bacteria? Role of complement activation, J Dent Res, vol.94, pp.1765-72, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01414092

G. Huang, S. Gronthos, and S. Shi, Mesenchymal stem cells derived from dental tissues vs. those from other sources, J Dent Res, vol.88, pp.792-806, 2009.

M. Miura, S. Gronthos, M. Zhao, B. Lu, L. W. Fisher et al., SHED: stem cells from human exfoliated deciduous teeth, Proc Natl Acad Sci U S A, vol.100, pp.5807-5819, 2003.

W. Sonoyama, Y. Liu, D. Fang, T. Yamaza, B. Seo et al., Mesenchymal stem cell-mediated functional tooth regeneration in swine, PloS One, vol.1, p.79, 2006.

P. Laurent, J. Camps, and I. About, Biodentine(TM) induces TGF-?1 release from human pulp cells and early dental pulp mineralization, Int Endod J, vol.45, pp.439-487, 2012.

C. Jeanneau, P. Laurent, C. Rombouts, G. T. About, and I. , Light-cured tricalcium silicate toxicity to the dental pulp, J Endod, vol.43, pp.2074-80, 2017.

F. Chmilewsky, C. Jeanneau, P. Laurent, M. Kirschfink, and I. About, Pulp progenitor cell recruitment is selectively guided by a C5a gradient, J Dent Res, vol.92, pp.532-541, 2013.

P. Rufas, C. Jeanneau, C. Rombouts, P. Laurent, and I. About, Complement C3a mobilizes dental pulp stem cells and specifically guides pulp fibroblast recruitment, J Endod, vol.42, pp.1377-84, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01458926

F. Chmilewsky, C. Jeanneau, J. Dejou, and I. About, Sources of dentin-pulp regeneration signals and their modulation by the local microenvironment, J Endod, vol.40, pp.19-25, 2014.

C. Prati and M. G. Gandolfi, Calcium silicate bioactive cements: biological perspectives and clinical applications, Dent Mater Off Publ Acad Dent Mater, vol.31, pp.351-70, 2015.

J. Camilleri, F. E. Montesin, K. Brady, R. Sweeney, R. V. Curtis et al., The constitution of mineral trioxide aggregate, Dent Mater Off Publ Acad Dent Mater, vol.21, pp.297-303, 2005.

A. E. Dawood, P. Parashos, R. Wong, E. C. Reynolds, and D. J. Manton, Calcium silicate-based cements: composition, properties, and clinical applications, J Investig Clin Dent, vol.8, p.12195, 2017.

M. Vallés, M. Mercadé, F. Duran-sindreu, J. L. Bourdelande, and M. Roig, Color stability of white mineral trioxide aggregate, Clin Oral Investig, vol.17, pp.1155-1164, 2013.

M. Vallés, M. Roig, F. Duran-sindreu, S. Martínez, and M. Mercadé, Color stability of teeth restored with biodentine: a 6-month in vitro study, J Endod, vol.41, pp.1157-60, 2015.

M. Torabinejad, C. U. Hong, F. Mcdonald, P. Ford, and T. R. , Physical and chemical properties of a new root-end filling material, J Endod, vol.21, pp.349-53, 1995.

I. About, Recent Trends in Tricalcium Silicates for Vital Pulp Therapy, Curr Oral Health Rep, vol.5, pp.178-85, 2018.

I. About, Cytotoxicity: mechanisms and in vivo studies, Biocompatibility or cytotoxic effects of dental composites, pp.91-110, 2009.

J. Camilleri, F. Sorrentino, and D. Damidot, Investigation of the hydration and bioactivity of radiopacified tricalcium silicate cement, Biodentine and MTA Angelus, Dent Mater Off Publ Acad Dent Mater, vol.29, pp.580-93, 2013.

L. C. Natale, M. C. Rodrigues, T. A. Xavier, A. Simões, D. N. De-souza et al., Ion release and mechanical properties of calcium silicate and calcium hydroxide materials used for pulp capping, Int Endod J, vol.48, pp.89-94, 2015.

J. Camilleri, Hydration characteristics of biodentine and theracal used as pulp capping materials, Dent Mater Off Publ Acad Dent Mater, vol.30, pp.709-724, 2014.

M. Aeinehchi, B. Eslami, M. Ghanbariha, and A. S. Saffar, Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report, Int Endod J, vol.36, pp.225-260, 2003.

O. Téclès, P. Laurent, V. Aubut, and I. About, Human tooth culture: a study model for reparative dentinogenesis and direct pulp capping materials biocompatibility, J Biomed Mater Res B Appl Biomater, vol.85, pp.180-187, 2008.

U. Schröder, Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation, J Dent Res, vol.64, pp.541-549, 1985.

U. Schröder and B. Sundström, Transmission electron microscopy of tissue changes following experimental pulpotomy of intact human teeth and capping with calcium hydroxide, Odontol Revy, vol.25, pp.57-68, 1974.

J. Camilleri, P. Laurent, and I. About, Hydration of biodentine, theracal LC, and a prototype tricalcium silicate-based dentin replacement material after pulp capping in entire tooth cultures, J Endod, vol.40, pp.1846-54, 2014.

S. An, Y. Gao, J. Ling, X. Wei, and Y. Xiao, Calcium ions promote osteogenic differentiation and mineralization of human dental pulp cells: implications for pulp capping materials, J Mater Sci Mater Med, vol.23, pp.789-95, 2012.

R. C. Bielby, I. S. Christodoulou, R. S. Pryce, W. Radford, L. L. Hench et al., Time-and concentration-dependent effects of dissolution products of 58S sol-gel bioactive glass on proliferation and differentiation of murine and human osteoblasts, Tissue Eng, vol.10, pp.1018-1044, 2004.

M. Massler, Pulpal reactions to dental caries, Int Dent J, vol.17, pp.441-60, 1967.

I. Kim, S. O. Moon, S. H. Kim, H. J. Kim, Y. S. Koh et al., Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells, J Biol Chem, vol.276, pp.7614-7634, 2001.

S. Hippenstiel, M. Krüll, A. Ikemann, W. Risau, M. Clauss et al., VEGF induces hyperpermeability by a direct action on endothelial cells, Am J Physiol, vol.274, pp.678-84, 1998.

P. C. Heinrich, J. V. Castell, and T. Andus, Interleukin-6 and the acute phase response, Biochem J, vol.265, pp.621-657, 1990.

R. Guo and P. A. Ward, Role of C5a in inflammatory responses, Annu Rev Immunol, vol.23, pp.821-52, 2005.

P. Bindal, T. S. Ramasamy, N. Kasim, N. Gnanasegaran, and W. L. Chai, Immune responses of human dental pulp stem cells in lipopolysaccharide-induced microenvironment, Cell Biol Int, vol.42, pp.832-872, 2018.

T. Giraud, C. Jeanneau, M. Bergmann, P. Laurent, and I. About, Tricalcium silicate capping materials modulate pulp healing and inflammatory activity in vitro, J Endod, p.0, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01960530

B. N. Cavalcanti, S. M. Rode-de, C. M. França, and M. M. Marques, Pulp capping materials exert an effect on the secretion of IL-1? and IL-8 by migrating human neutrophils, Braz Oral Res, vol.25, pp.13-21, 2011.

C. Kang, J. Hwang, J. S. Song, J. Lee, H. Choi et al., Effects of three calcium silicate cements on inflammatory response and mineralization-inducing potentials in a dog pulpotomy model, Mater Basel Switz, vol.11, 2018.

A. L. Jalan, M. M. Warhadpande, and D. M. Dakshindas, A comparison of human dental pulp response to calcium hydroxide and biodentine as direct pulp-capping agents, J Conserv Dent JCD, vol.20, pp.129-162, 2017.

E. Karim, I. A. Mccrudden, M. Mcgahon, M. K. Curtis, T. M. Jeanneau et al., Biodentine reduces tumor necrosis factor alpha-induced trpa1 expression in odontoblastlike cells, J Endod, vol.42, pp.589-95, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01454774

I. About, Dentin-pulp regeneration: the primordial role of the microenvironment and its modification by traumatic injuries and bioactive materials, p.28, 2013.

S. Mathieu, C. Jeanneau, N. Sheibat-othman, N. Kalaji, H. Fessi et al., Usefulness of controlled release of growth factors in investigating the early events of dentin-pulp regeneration, J Endod, vol.39, pp.228-263, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00925125

W. Zhang, X. F. Walboomers, and J. A. Jansen, The formation of tertiary dentin after pulp capping with a calcium phosphate cement, loaded with PLGA microparticles containing TGF-beta1, J Biomed Mater Res A, vol.85, pp.439-483, 2008.

T. Giraud, P. Rufas, F. Chmilewsky, C. Rombouts, J. Dejou et al., Complement activation by pulp capping materials plays a significant role in both inflammatory and pulp stem cells' recruitment, J Endod, vol.43, pp.1104-1114, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01691140

H. Bakhtiar, M. H. Nekoofar, P. Aminishakib, F. Abedi, N. Moosavi et al., Human pulp responses to partial pulpotomy treatment with theracal as compared with biodentine and ProRoot MTA: a clinical trial, J Endod, vol.43, pp.1786-91, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01691174

C. Cuadros-fernández, L. Rodríguez, A. I. Sáez-martínez, S. García-binimelis, J. About et al., Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial, Clin Oral Investig, vol.20, pp.1639-1684, 2016.

A. Nowicka, M. Lipski, M. Parafiniuk, K. Sporniak-tutak, D. Lichota et al., Response of human dental pulp capped with biodentine and mineral trioxide aggregate, J Endod, vol.39, pp.743-750, 2013.

A. Nowicka, G. Wilk, M. Lipski, J. Ko?ecki, and J. Buczkowska-radli?ska, Tomographic evaluation of reparative dentin formation after direct pulp capping with Ca(OH) 2 , mta, biodentine, and dentin bonding system in human teeth, J Endod, vol.41, pp.1234-1274, 2015.

H. Lee, Y. Shin, S. Kim, H. Lee, H. Choi et al., Comparative study of pulpal responses to pulpotomy with ProRoot MTA, RetroMTA, and TheraCal in Dogs' teeth, J Endod, vol.41, pp.1317-1341, 2015.

J. Hebling, F. Lessa, I. Nogueira, R. M. Carvalho, and C. Costa, Cytotoxicity of resin-based light-cured liners, Am J Dent, vol.22, pp.137-179, 2009.

E. Diamanti, S. Mathieu, C. Jeanneau, E. Kitraki, P. Panopoulos et al., Endoplasmic reticulum stress and mineralization inhibition mechanism by the resinous monomer HEMA, Int Endod J, vol.46, pp.160-168, 2013.

N. A. Taha and S. Z. Abdelkhader, Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis, Int Endod J, vol.51, pp.819-847, 2018.

N. A. Taha and S. Z. Abdulkhader, Full pulpotomy with biodentine in symptomatic young permanent teeth with carious exposure, J Endod, vol.44, pp.932-939, 2018.

N. A. Taha and M. A. Khazali, Partial pulpotomy in mature permanent teeth with clinical signs indicative of irreversible pulpitis: a randomized clinical trial, J Endod, vol.43, pp.1417-1438, 2017.

S. Asgary, M. J. Eghbal, and A. A. Bagheban, Long-term outcomes of pulpotomy in permanent teeth with irreversible pulpitis: A multi-center randomized controlled trial, Am J Dent, vol.30, pp.151-156, 2017.

C. Jeanneau, F. T. Lundy, E. Karim, I. A. About, and I. , Potential therapeutic strategy of targeting pulp fibroblasts in dentin-pulp regeneration, J Endod, vol.43, pp.17-24, 2017.

M. Nakashima and K. Iohara, Regeneration of dental pulp by stem cells, Adv Dent Res, vol.23, pp.313-322, 2011.

J. Farges, B. Alliot-licht, R. E. Ducret, M. Gaudin, A. Smith et al., Dental pulp defence and repair mechanisms in dental caries, Mediators Inflamm, p.230251, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-02146799