Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy
Caroline Klingebiel
(1)
,
Yannick Chantran
(2, 3)
,
Rihane Arif‐lusson
(4, 5)
,
Angelica Ehrenberg
(6)
,
Jonas Östling
(6)
,
Alain Poisson
(7)
,
Valérie Liabeuf
(8)
,
Chantal Agabriel
(9)
,
Joëlle Birnbaum
(10)
,
Françoise Porri
(7)
,
Anne Sarrat
(11)
,
Pol-André Apoil
(12)
,
Mylène Vivinus
(13)
,
Lorna Garnier
(14)
,
Anca Mirela Chiriac
(15, 16, 17)
,
Davide‐paolo Caimmi
(15, 17, 18)
,
Jean‐luc Bourrain
(15, 18)
,
Pascal Demoly
(18, 17, 15)
,
Stéphane Guez
(19)
,
Franck Boralevi
(20)
,
Bertrand Lovato
(21)
,
Céline Palussière
(22)
,
Sylvie Leroy
(23)
,
Thierry Bourrier
(24)
,
Lisa Giovannini‐chami
(24)
,
Marion Gouitaa
(25)
,
Agnès Aferiat‐derome
(26)
,
Denis Charpin
(27)
,
Tünde Sofalvi
(25)
,
Isabelle Cabon‐boudard
(25)
,
Yann‐patrick Massabie‐bouchat
(26)
,
Bernard Hofmann
(28)
,
Nathalie Bonardel
(15)
,
Mireille Dron‐gonzalvez
(29)
,
Benoît Sterling
(27)
,
Ania Carsin
(27)
,
Serge Vivinus
(23)
,
Bernard Poitevin
(30)
,
Laureline Nicolau
(31)
,
Geneviève Liautard
(32)
,
Christophe Soler
(1)
,
Soraya Mezouar
(4)
,
Isabella Annesi-Maesano
(33)
,
Jean-Louis Mege
(5, 4)
,
Jonas Lidholm
(6)
,
Joana Vitte
(5, 4)
1
Laboratoire Synlab Provence
2 Laboratoire d'Hématologie et d'Immunologie [CHU Saint-Antoine]
3 UMRS893 - Centre de Recherche Saint-Antoine
4 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
5 MEPHI - Microbes évolution phylogénie et infections
6 Thermo Fisher Scientific (Bremen) GmbH
7 Hôpital Saint-Joseph [Marseille]
8 Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM]
9 Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]
10 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
11 Service d'immunologie et d'immunogénétique [Bordeaux]
12 Institut Fédératif de Biologie (IFB)
13 CHU - Hôpital Archet 2 [Nice]
14 Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]
15 Département pneumologie et addictologie [Montpellier]
16 UM - Université de Montpellier
17 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
18 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
19 CHU Bordeaux [Bordeaux]
20 Hôpital Pellegrin
21 Centre Médical de Mérignac
22 Centre Médical de Cenon
23 CHU - Hôpital Pasteur [Nice]
24 CHU-Lenval - Hôpitaux Pédiatriques de Nice Lenval
25 APHM - Assistance Publique - Hôpitaux de Marseille
26 Espace Médical Castellane
27 TIMONE - Hôpital de la Timone [CHU - APHM]
28 Centre Hospitalier de Carpentras
29 Centre Hospitalier de Martigues
30 Centre hospitalier de Bormes-les-Mimosas
31 Centre Hospitalier Saint Jean de Perpignan
32 Centre Hospitalier de Solliès-Pont
33 Epidémiologie, Systèmes d'Information, Modélisation
2 Laboratoire d'Hématologie et d'Immunologie [CHU Saint-Antoine]
3 UMRS893 - Centre de Recherche Saint-Antoine
4 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
5 MEPHI - Microbes évolution phylogénie et infections
6 Thermo Fisher Scientific (Bremen) GmbH
7 Hôpital Saint-Joseph [Marseille]
8 Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM]
9 Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]
10 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
11 Service d'immunologie et d'immunogénétique [Bordeaux]
12 Institut Fédératif de Biologie (IFB)
13 CHU - Hôpital Archet 2 [Nice]
14 Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]
15 Département pneumologie et addictologie [Montpellier]
16 UM - Université de Montpellier
17 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
18 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
19 CHU Bordeaux [Bordeaux]
20 Hôpital Pellegrin
21 Centre Médical de Mérignac
22 Centre Médical de Cenon
23 CHU - Hôpital Pasteur [Nice]
24 CHU-Lenval - Hôpitaux Pédiatriques de Nice Lenval
25 APHM - Assistance Publique - Hôpitaux de Marseille
26 Espace Médical Castellane
27 TIMONE - Hôpital de la Timone [CHU - APHM]
28 Centre Hospitalier de Carpentras
29 Centre Hospitalier de Martigues
30 Centre hospitalier de Bormes-les-Mimosas
31 Centre Hospitalier Saint Jean de Perpignan
32 Centre Hospitalier de Solliès-Pont
33 Epidémiologie, Systèmes d'Information, Modélisation
Anca Mirela Chiriac
- Function : Author
- PersonId : 1164876
- IdHAL : anca-mirela-chiriac
Davide‐paolo Caimmi
- Function : Author
- PersonId : 754264
- IdHAL : davidecaimmi
- ORCID : 0000-0003-4481-6194
- IdRef : 190361816
Jean‐luc Bourrain
- Function : Author
- PersonId : 754710
- IdHAL : jean-luc-bourrain
- ORCID : 0000-0002-9501-9331
Pascal Demoly
- Function : Author
- PersonId : 754222
- IdHAL : pascal-demoly
- ORCID : 0000-0001-7827-7964
- IdRef : 03442959X
Soraya Mezouar
- Function : Author
- PersonId : 780881
- IdHAL : soraya-mezouar
- ORCID : 0000-0002-2285-7051
Isabella Annesi-Maesano
- Function : Author
- PersonId : 754596
- IdHAL : isabella-annesi-maesano
- ORCID : 0000-0002-6340-9300
- IdRef : 123241847
Jean-Louis Mege
- Function : Author
- PersonId : 932374
Joana Vitte
- Function : Author
- PersonId : 754717
- IdHAL : joana-vitte
- ORCID : 0000-0002-3344-9408
- IdRef : 095980806
Abstract
BACKGROUND:
Peach is a common elicitor of food allergic reactions. Peach-induced immediate reactions may occur as benign pollen-food syndromes, usually due to birch pollen-related PR-10 cross-reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has gained recent attention as a potential peach allergy severity marker. Sensitization to Pru p 7 and its allergenic homologues of the gibberellin-regulated protein family occurs in areas with high Cupressaceae tree pollen exposure.
OBJECTIVE:
We sought to investigate the distribution, clinical characteristics and molecular associations of Pru p 7 sensitization among subjects with suspected peach allergy in different regions of France.
METHODS:
Subjects with suspected peach allergy (n = 316) were included. Diagnostic work-up was performed according to current guidelines, including open food challenge when required. IgE antibody measurements and competition experiments were performed using the ImmunoCAP assay platform.
RESULTS:
Sensitization to Pru p 7 was present in 171 (54%) of all subjects in the study and in 123 of 198 (62%) diagnosed as peach allergic, more than half of whom were sensitized to no other peach allergen. Frequency and magnitude of Pru p 7 sensitization were associated with the presence of peach allergy, the clinical severity of peach-induced allergic reactions and the level of cypress pollen exposure. Cypress pollen extract completely outcompeted IgE binding to Pru p 7. Pru p 7 was extremely potent in basophil activation tests.
CONCLUSION AND CLINICAL RELEVANCE:
A subtype of Cupressaceae pollinosis, characterized by Pru p 7 sensitization, can be an underlying cause of severe peach allergy.
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