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Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy

Caroline Klingebiel 1 Yannick Chantran 2, 3 Rihane Arif‐lusson 4, 5 Angelica Ehrenberg 6 Jonas Östling 6 Alain Poisson 7 Valérie Liabeuf 8 Chantal Agabriel 9 Joëlle Birnbaum 10 Françoise Porri 7 Anne Sarrat 11 Pol-André Apoil 12 Mylène Vivinus 13 Lorna Garnier 14 Anca Mirela Chiriac 15, 16, 17 Davide‐paolo Caimmi 15, 17, 18 Jean‐luc Bourrain 15, 18 Pascal Demoly 18, 17, 15 Stéphane Guez 19 Franck Boralevi 20 Bertrand Lovato 21 Céline Palussière 22 Sylvie Leroy 23 Thierry Bourrier 24 Lisa Giovannini‐chami 24 Marion Gouitaa 25 Agnès Aferiat‐derome 26 Denis Charpin 27 Tünde Sofalvi 25 Isabelle Cabon‐boudard 25 Yann‐patrick Massabie‐bouchat 26 Bernard Hofmann 28 Nathalie Bonardel 15 Mireille Dron‐gonzalvez 29 Benoît Sterling 27 Ania Carsin 27 Serge Vivinus 23 Bernard Poitevin 30 Laureline Nicolau 31 Geneviève Liautard 32 Christophe Soler 1 Soraya Mezouar 4 Isabella Annesi-Maesano 33 Jean-Louis Mege 5, 4 Jonas Lidholm 6 Joana Vitte 5, 4
1 Laboratoire Synlab Provence
2 Laboratoire d'Hématologie et d'Immunologie [CHU Saint-Antoine]
3 UMRS893 - Centre de Recherche Saint-Antoine
4 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection
5 MEPHI - Microbes évolution phylogénie et infections
6 Thermo Fisher Scientific (Bremen) GmbH
7 Hôpital Saint-Joseph [Marseille]
8 Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM]
9 Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]
10 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
11 Service d'immunologie et d'immunogénétique [Bordeaux]
12 Institut Fédératif de Biologie (IFB) - Hôpital Purpan
13 CHU - Hôpital Archet 2 [Nice]
14 Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]
15 Département pneumologie et addictologie [Montpellier]
16 UM - Université de Montpellier
17 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
18 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
19 CHU Bordeaux [Bordeaux]
20 Hôpital Pellegrin
21 Centre Médical de Mérignac
22 Centre Médical de Cenon
23 CHU - Hôpital Pasteur [Nice]
24 CHU-Lenval - Hôpitaux Pédiatriques de Nice Lenval
25 APHM - Assistance Publique - Hôpitaux de Marseille
26 Espace Médical Castellane
27 TIMONE - Hôpital de la Timone [CHU - APHM]
28 Centre Hospitalier de Carpentras
29 Centre Hospitalier de Martigues
30 Centre hospitalier de Bormes-les-Mimosas
31 Centre Hospitalier Saint Jean de Perpignan
32 Centre Hospitalier de Solliès-Pont
33 Epidémiologie, Systèmes d'Information, Modélisation
Abstract : BACKGROUND: Peach is a common elicitor of food allergic reactions. Peach-induced immediate reactions may occur as benign pollen-food syndromes, usually due to birch pollen-related PR-10 cross-reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has gained recent attention as a potential peach allergy severity marker. Sensitization to Pru p 7 and its allergenic homologues of the gibberellin-regulated protein family occurs in areas with high Cupressaceae tree pollen exposure. OBJECTIVE: We sought to investigate the distribution, clinical characteristics and molecular associations of Pru p 7 sensitization among subjects with suspected peach allergy in different regions of France. METHODS: Subjects with suspected peach allergy (n = 316) were included. Diagnostic work-up was performed according to current guidelines, including open food challenge when required. IgE antibody measurements and competition experiments were performed using the ImmunoCAP assay platform. RESULTS: Sensitization to Pru p 7 was present in 171 (54%) of all subjects in the study and in 123 of 198 (62%) diagnosed as peach allergic, more than half of whom were sensitized to no other peach allergen. Frequency and magnitude of Pru p 7 sensitization were associated with the presence of peach allergy, the clinical severity of peach-induced allergic reactions and the level of cypress pollen exposure. Cypress pollen extract completely outcompeted IgE binding to Pru p 7. Pru p 7 was extremely potent in basophil activation tests. CONCLUSION AND CLINICAL RELEVANCE: A subtype of Cupressaceae pollinosis, characterized by Pru p 7 sensitization, can be an underlying cause of severe peach allergy.
Keywords : immunological tests IgE food allergy cypress pollinosis basophil allergens and epitopes anaphylaxis peamaclein Pru p 7
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Submitted on : Monday, October 14, 2019 - 11:51:56 AM
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UNIV-AMU | IPLESP | HCL | SU-MEDECINE | CNRS | CHLS | IRD | INSERM | SU-TI | SORBONNE-UNIVERSITE | UNIV-TLSE3 | INFINITY | UNIV-MONTPELLIER | U938

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Caroline Klingebiel, Yannick Chantran, Rihane Arif‐lusson, Angelica Ehrenberg, Jonas Östling, et al.. Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy. Clinical and Experimental Allergy, Wiley, 2019, 49 (4), pp.526-536. ⟨10.1111/cea.13345⟩. ⟨hal-02202464⟩

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