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Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy

Caroline Klingebiel 1 Yannick Chantran 2, 3, 4 Rihane Arif‐lusson 5 Angelica Ehrenberg 6 Jonas Östling 6 Alain Poisson 7 Valérie Liabeuf 8 Chantal Agabriel 8 Joëlle Birnbaum 9 Françoise Porri 7 Anne Sarrat 10 Pol‐andré Apoil 11 Mylène Vivinus 12 Lorna Garnier 13 Anca Mirela Chiriac 14, 15, 4 Davide‐paolo Caimmi 14, 15, 4 Jean‐luc Bourrain 16 Pascal Demoly 17, 15, 4 Stéphane Guez 10 Franck Boralevi 18 Bertrand Lovato 19 Céline Palussière 20 Sylvie Leroy 21 Thierry Bourrier 22 Lisa Giovannini‐chami 22 Marion Gouitaa 23 Agnès Aferiat‐derome 24 Denis Charpin 8 Tünde Sofalvi 23 Isabelle Cabon‐boudard 23 Yann‐patrick Massabie‐bouchat 24 Bernard Hofmann 25 Nathalie Bonardel 26 Mireille Dron‐gonzalvez 27 Benoît Sterling 8 Ania Carsin 8 Serge Vivinus 21 Bernard Poitevin 28 Laureline Nicolau 29 Geneviève Liautard 30 Christophe Soler 1 Soraya Mezouar 31 Isabella Annesi-Maesano 32 Jean-Louis Mege 5 Jonas Lidholm 6 Joana Vitte 5
1 Laboratoire Synlab Provence
2 CR Saint-Antoine - Centre de Recherche Saint-Antoine
3 CHU Saint-Antoine [AP-HP]
4 SU - Sorbonne Université
5 MEPHI - Microbes évolution phylogénie et infections
6 Thermo Fisher Scientific (Bremen) GmbH
7 Hôpital Saint-Joseph [Marseille]
8 TIMONE - Hôpital de la Timone [CHU - APHM]
9 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
10 CHU Bordeaux [Bordeaux]
11 Hôpital Purpan [Toulouse]
12 CHU - Hôpital Archet 2 [Nice]
13 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
14 CHU Montpellier
15 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
16 CHU - Hôpital Lapeyronie [Montpellier]
17 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
18 Hôpital Pellegrin
19 Centre Médical de Mérignac
20 Centre Médical de Cenon
21 CHU - Hôpital Pasteur [Nice]
22 CHU-Lenval - Hôpitaux Pédiatriques de Nice Lenval
23 APHM - Assistance Publique - Hôpitaux de Marseille
24 Espace Médical Castellane
25 Centre Hospitalier de Carpentras
26 Département pneumologie et addictologie [Montpellier]
27 Centre Hospitalier de Martigues
28 Centre hospitalier de Bormes-les-Mimosas
29 Centre Hospitalier Saint Jean de Perpignan
30 Centre Hospitalier de Solliès-Pont
31 IHU AMU - Institut Hospitalier Universitaire Méditerranée Infection
32 Epidémiologie, Systèmes d'Information, Modélisation
Abstract : BACKGROUND: Peach is a common elicitor of food allergic reactions. Peach-induced immediate reactions may occur as benign pollen-food syndromes, usually due to birch pollen-related PR-10 cross-reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has gained recent attention as a potential peach allergy severity marker. Sensitization to Pru p 7 and its allergenic homologues of the gibberellin-regulated protein family occurs in areas with high Cupressaceae tree pollen exposure. OBJECTIVE: We sought to investigate the distribution, clinical characteristics and molecular associations of Pru p 7 sensitization among subjects with suspected peach allergy in different regions of France. METHODS: Subjects with suspected peach allergy (n = 316) were included. Diagnostic work-up was performed according to current guidelines, including open food challenge when required. IgE antibody measurements and competition experiments were performed using the ImmunoCAP assay platform. RESULTS: Sensitization to Pru p 7 was present in 171 (54%) of all subjects in the study and in 123 of 198 (62%) diagnosed as peach allergic, more than half of whom were sensitized to no other peach allergen. Frequency and magnitude of Pru p 7 sensitization were associated with the presence of peach allergy, the clinical severity of peach-induced allergic reactions and the level of cypress pollen exposure. Cypress pollen extract completely outcompeted IgE binding to Pru p 7. Pru p 7 was extremely potent in basophil activation tests. CONCLUSION AND CLINICAL RELEVANCE: A subtype of Cupressaceae pollinosis, characterized by Pru p 7 sensitization, can be an underlying cause of severe peach allergy.
Keywords : immunological tests IgE food allergy cypress pollinosis basophil allergens and epitopes anaphylaxis peamaclein Pru p 7
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UNIV-AMU | SU-MEDECINE | SORBONNE-UNIVERSITE | IPLESP | U938 | CHLS | CNRS | HCL | IRD | UNIV-COTEDAZUR

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Caroline Klingebiel, Yannick Chantran, Rihane Arif‐lusson, Angelica Ehrenberg, Jonas Östling, et al.. Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy. Clinical and Experimental Allergy, Wiley, 2019, 49 (4), pp.526-536. ⟨10.1111/cea.13345⟩. ⟨hal-02202464⟩

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