Cystic fibrosis in the modern therapeutic era: Give the shower a thought!

Deborah Le Pennec (1) , Melisande Baravalle-Einaudi (2) , Christian Dupont (3) , Laurent Vecellio (1) , Jean-Christophe Dubus (2, 4)

1 UT - Université de Tours
2 TIMONE - Hôpital de la Timone [CHU - APHM]
3 Hôpital Cochin [AP-HP]
4 MEPHI - Microbes évolution phylogénie et infections

Fifty-two meshes of e-flow rapid® were characterized for tobramycin delivery with a laser diffractometer after 6 months of home use by cystic fibrosis patients treated with various nebulized drugs. Three meshes were out of order and 30 considered to be defective for tobramycin delivery. The use of the specific mesh cleaning shower system permitted 14 defective meshes to be in the expected range of nebulized volume.

Keywords: Cystic fibrosis; Mesh-nebulizer; In vitro study; Tobramycin

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Deborah Le Pennec, Melisande Baravalle-Einaudi, Christian Dupont, Laurent Vecellio, Jean-Christophe Dubus. Cystic fibrosis in the modern therapeutic era: Give the shower a thought!. Journal of Cystic Fibrosis, 2019, 18 (6), pp.e56-e57. ⟨10.1016/j.jcf.2019.03.004⟩. ⟨hal-02262513⟩