Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial

Philippe Merle , Jean-Frederic Blanc , Jean-Marc Phélip , Gilles Pelletier , Jean-Pierre Bronowicki , Yann Touchefeu , Georges Pageaux (1, 2) , Rene Gerolami (3, 4) , François Habersetzer , Eric Nguyen-Khac , Andrea Casadei-Gardini , Ivan Borbath , Albert Tran , Henning Wege , Amr Shafik Saad , Massimo Colombo , Armand Abergel , Carine Richou , Imam Waked , Nelson Yee , Audrey Molé , Pierre Attali , Julie Le Boulicaut , Bérangère Vasseur , Driffa Moussata , Jean-Didier Grangé , Vlad Ratziu , Faiza Khemissa-Akouz , Hélène Régnault , Barbara Dauvois , Jean-Pierre Zarski , Isabelle Ollivier-Hourmand , Sylvain Manfredi , Marilyne Debette-Gratien (5) , Alice Gangloff (6) , Thierry Fontanges , Aurore Baron , Mohamed Bouattour , Julie Vincent , Wolfgang Sieghart , Andrea Maieron , Marc Peeters , Jean Delwaide , Luc Lasser , Thomas Berg , Michael Schultheiss , Alexander Zipprich , Joerg Trojan , Ursula Ehmer , Gabriele Luppi , Luc Luca , Stefano Tamberi , Domenico Amoroso , Oscar Alabiso , Angela Buonadonna , Pierluigi Toniutto , Emiliano Tamburini , Antonio Cubillo , Andrés Muñoz , Carmen Guillén , Gloria Sánchez , Hermini Manzano , Victor Navarro , Inmaculada Ales , Bartomeu Massuti , Magdolna Dank , György Bodoky , Zsuzsanna Kahan , Zsolt Horváth , Nashat Gabrail , Howard Ozer , Christos Galanopoulos , Ralph Hauke , Moses Raj , Hakan Harputluoglu , Alper Sevinc , Erdem Goker , Ahmet Coker , Suayib Yalcin , Muhammet Ali , Ozlem Ata , Ilkay Tugba , Mohammed El Kassas , Amr Abdel , Imam Wakid , Sameh Shamaa , Nasr El Lahlouby , Hanaa Kohail , Jawad Makarem , Issam Chehade , Fadi Farhat , Carlos Lopez , Miguel Marín

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
3 MEPHI - Microbes évolution phylogénie et infections
4 APHM - Assistance Publique - Hôpitaux de Marseille
5 Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges]
6 Service d'Hépato-Gastroentérologie [CHU Rouen]

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Philippe Merle, Jean-Frederic Blanc, Jean-Marc Phélip, Gilles Pelletier, Jean-Pierre Bronowicki, et al.. Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial. The Lancet Gastroenterology & Hepatology, 2019, 4 (6), pp.454-465. ⟨10.1016/S2468-1253(19)30040-8⟩. ⟨hal-02262527⟩