H. Alnaseri, B. Arsic, J. E. Schneider, J. C. Kaiser, Z. C. Scinocca et al., Inducible expression of a resistance-nodulation-divisiontype efflux pump in Staphylococcus aureus provides resistance to linoleic and arachidonic acids, J. Bacteriol, vol.197, pp.1893-1905, 2015.

T. Bae and O. Schneewind, Allelic replacement in Staphylococcus aureus with inducible counter-selection, Plasmid, vol.55, pp.58-63, 2006.

E. G. Bligh and W. J. Dyer, A rapid method of total lipid extraction and purification, Can. J. Biochem. Physiol, vol.37, pp.911-917, 1959.

A. Cherkaoui, S. M. Diene, A. Fischer, S. Leo, P. Francois et al., Transcriptional modulation of penicillin-binding protein 1b, outer membrane protein P2 and efflux pump (AcrAB-TolC) during heat stress is correlated to enhanced bactericidal action of imipenem on non-typeable Haemophilus influenzae, Front. Microbiol, vol.8, p.2676, 2017.

G. Y. Cheung, H. S. Joo, S. S. Chatterjee, and M. Otto, Phenol-soluble modulins-critical determinants of staphylococcal virulence, FEMS Microbiol. Rev, vol.38, pp.698-719, 2014.

S. Dachriyanus, M. V. Sargent, B. W. Skelton, I. Soediro, and M. Sutisna, , 2002.

, Rhodomyrtone, an antibiotic from Rhodomyrtus tomentosa, Aus. J. Chem, vol.55, pp.229-232

P. Ebner, A. Luqman, S. Reichert, K. Hauf, P. Popella et al., Non-classical protein excretion is boosted by psmalpha-induced cell leakage, Cell. Rep, vol.20, pp.1278-1286, 2017.

P. Ebner, M. Prax, M. Nega, I. Koch, L. Dube et al., Excretion of cytoplasmic proteins (ECP) in Staphylococcus aureus, Mol. Microbiol, vol.97, pp.775-789, 2015.

M. E. Ericson, C. Subramanian, M. W. Frank, and C. O. Rock, Role of fatty acid kinase in cellular lipid homeostasis and SaeRS-dependent virulence factor expression in Staphylococcus aureus, MBio, vol.8, pp.988-917, 2017.

S. Fuchs, H. Mehlan, J. Bernhardt, A. Hennig, S. Michalik et al., AureoWiki The repository of the Staphylococcus aureus research and annotation community, Int. J. Med. Microbiol, vol.308, pp.558-568, 2018.

T. Geiger, P. Francois, M. Liebeke, M. Fraunholz, C. Goerke et al., The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression, PLoS Pathog, vol.8, p.1003016, 2012.

D. G. Gibson, L. Young, R. Y. Chuang, J. C. Venter, C. A. Hutchison et al., Enzymatic assembly of DNA molecules up to several hundred kilobases, Nat. Methods, vol.6, pp.343-345, 2009.

D. Hanzelmann, H. S. Joo, M. Franz-wachtel, T. Hertlein, S. Stevanovic et al., Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants, Nat. Commun, vol.7, p.12304, 2016.

S. Herbert, A. K. Ziebandt, K. Ohlsen, T. Schafer, M. Hecker et al., Repair of global regulators in Staphylococcus aureus 8325 and comparative analysis with other clinical isolates, Infect. Immun, vol.78, pp.2877-2889, 2010.

T. Kantyka, K. Plaza, J. Koziel, D. Florczyk, H. R. Stennicke et al., Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence, Biol. Chem, vol.392, pp.483-489, 2011.

S. Leejae, B. E. Yingyongnarongkul, A. Suksamrarn, and S. P. Voravuthikunchai, Synthesis and structure-activity relationship of rhodomyrtone derivatives as antibacterial agent, Chin. Chem. Lett, vol.23, pp.1011-1014, 2012.

S. Limsuwan, A. Hesseling-meinders, S. P. Voravuthikunchai, J. M. Van-dijl, and O. Kayser, Potential antibiotic and anti-infective effects of rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. on Streptococcus pyogenes as revealed by proteomics, Phytomedicine, vol.18, pp.934-940, 2011.

Q. Liu, W. S. Yeo, and T. Bae, The SaeRS two-component system of Staphylococcus aureus, Genes, vol.7, p.81, 2016.

D. Ma, D. N. Cook, M. Alberti, N. G. Pon, H. Nikaido et al., , 1995.

, Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli, Mol. Microbiol, vol.16, pp.45-55

U. Mäder, P. Nicolas, M. Depke, J. Pane-farre, M. Debarbouille et al., Staphylococcus aureus transcriptome architecture: from laboratory to infection-mimicking conditions, PLoS Genet, vol.12, p.1005962, 2016.

I. R. Monk and T. J. Foster, Genetic manipulation of Staphylococcibreaking through the barrier, Front. Cell. Infect. Microbiol, vol.2, p.49, 2012.

M. Morkunas, L. Dube, F. Götz, and M. E. Maier, Synthesis of the acylphloroglucinols rhodomyrtone and rhodomyrtosone B, Tetrahedron, vol.69, pp.8559-8563, 2013.

M. Morkunas and M. E. Maier, Alternative routes to the acylphloroglucinol rhodomyrtone, Tetrahedron, vol.71, pp.9662-9666, 2015.

A. Mortazavi, B. A. Williams, K. Mccue, L. Schaeffer, and B. Wold, Mapping and quantifying mammalian transcriptomes by RNA-Seq, Nat. Methods, vol.5, pp.621-628, 2008.

A. Nagel, S. Michalik, M. Debarbouille, T. Hertlein, M. Salazar et al., Inhibition of rho activity increases expression of SaeRSdependent virulence factor genes in Staphylococcus aureus, showing a link between transcription termination, antibiotic action, and virulence, MBio, vol.9, pp.1332-1318, 2018.

H. Nakamura, Genetic determination of resistance to acriflavine, phenethyl alcohol, and sodium dodecyl sulfate in Escherichia coli, J. Bacteriol, vol.96, pp.987-996, 1968.

M. T. Nguyen, D. Hanzelmann, T. Hartner, A. Peschel, and F. Götz, Skinspecific unsaturated fatty acids boost the Staphylococcus aureus innate immune response, Infect. Immun, vol.84, pp.205-215, 2015.

R. P. Novick, Autoinduction and signal transduction in the regulation of staphylococcal virulence, Mol Microbiol, vol.48, pp.1429-1449, 2003.

V. Pader, S. Hakim, K. L. Painter, S. Wigneshweraraj, T. B. Clarke et al., Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids, Nat. Microbiol, vol.2, p.16194, 2016.

J. B. Parsons, T. C. Broussard, J. L. Bose, J. W. Rosch, P. Jackson et al., Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus, Proc. Natl. Acad. Sci. U.S.A, vol.111, pp.10532-10537, 2014.

A. Peschel and M. Otto, Phenol-soluble modulins and staphylococcal infection, Nat. Rev. Microbiol, vol.11, pp.667-673, 2013.

J. L. Ramos, M. Martinez-bueno, A. J. Molina-henares, W. Teran, K. Watanabe et al., The TetR family of transcriptional repressors. Microbiol, Mol. Biol. Rev, vol.69, pp.326-356, 2005.

A. Rhoads and K. F. Au, PacBio sequencing and its applications, Genomics Proteomics Bioinformatics, vol.13, pp.278-289, 2015.

D. Saeloh, V. Tipmanee, K. K. Jim, M. P. Dekker, W. Bitter et al., The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity, PLoS Pathog, vol.14, p.1006876, 2018.

J. Saising, F. Götz, L. Dube, A. K. Ziebandt, and S. P. Voravuthikunchai, Inhibition of staphylococcal biofilm-related gene transcription by rhodomyrtone, a new antibacterial agent, Ann. Microbiol, vol.65, pp.659-665, 2014.

J. Saising, A. Hiranrat, W. Mahabusarakam, M. Ongsakul, and S. P. Voravuthikunchai, Rhodomyrtone from Rhodomyrtus tomentosa (Aiton) hassk. as a natural antibiotic for staphylococcal cutaneous infections, J. Health Sci, vol.54, pp.589-595, 2008.

J. Saising, M. T. Nguyen, T. Hartner, P. Ebner, A. Al-mamun-bhuyan et al., Rhodomyrtone (rom) is a membrane-active compound, Biochim. Biophys. Acta, vol.1860, pp.1114-1124, 2018.

J. Saising and S. P. Voravuthikunchai, Anti Propionibacterium acnes activity of rhodomyrtone, an effective compound from Rhodomyrtus tomentosa (Aiton) Hassk. leaves, Anaerobe, vol.18, pp.400-404, 2012.

G. R. Sampedro, A. C. Dedent, R. E. Becker, B. J. Berube, M. J. Gebhardt et al., Targeting Staphylococcus aureus alpha-toxin as a novel approach to reduce severity of recurrent skin and soft-tissue infections, J. Infect. Dis, vol.210, pp.1012-1018, 2014.

S. A. Short and D. C. White, Metabolism of phosphatidylglycerol, lysylphosphatidylglycerol, and cardiolipin of Staphylococcus aureus, J. Bacteriol, vol.108, pp.219-226, 1971.

W. Sianglum, P. Srimanote, P. W. Taylor, H. Rosado, and S. P. Voravuthikunchai, Transcriptome analysis of responses to rhodomyrtone in methicillinresistant Staphylococcus aureus, PLoS One, vol.7, p.45744, 2012.

W. Sianglum, P. Srimanote, W. Wonglumsom, K. Kittiniyom, and S. P. Voravuthikunchai, Proteome analyses of cellular proteins in methicillin-resistant Staphylococcus aureus treated with rhodomyrtone, a novel antibiotic candidate, Plos One, vol.6, p.16628, 2011.

J. Smagur, K. Guzik, M. Bzowska, M. Kuzak, M. Zarebski et al., Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages, Biol. Chem, vol.390, pp.361-371, 2009.

A. Strauss and F. Götz, In vivo immobilization of enzymatically active polypeptides on the cell surface of Staphylococcus carnosus, Mol. Microbiol, vol.21, pp.491-500, 1996.

R. L. Tatusov, N. D. Fedorova, J. D. Jackson, A. R. Jacobs, B. Kiryutin et al., The COG database: an updated version includes eukaryotes, BMC Bioinformatics, vol.4, p.41, 2003.

S. P. Voravuthikunchai, S. Dolah, and W. Charernjiratrakul, Control of Bacillus cereus in foods by Rhodomyrtus tomentosa (Ait.) Hassk. Leaf extract and its purified compound, J. Food Prot, vol.73, pp.1907-1912, 2010.

M. A. Webber, A. Talukder, and L. J. Piddock, Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates, Antimicrob. Agents Chemother, vol.49, pp.4390-4392, 2005.

K. P. Wieland, B. Wieland, and F. Götz, A promoter-screening plasmid and xylose-inducible, glucose-repressible expression vectors for Staphylococcus carnosus, Gene, vol.158, pp.91-96, 1995.

C. Wolz, P. Pohlmann-dietze, A. Steinhuber, Y. T. Chien, A. Manna et al., Agr-independent regulation of fibronectin-binding protein(s) by the regulatory locus sar in Staphylococcus aureus, Mol. Microbiol, vol.36, pp.230-243, 2000.

L. Zhao, H. Liu, L. Huo, M. Wang, B. Yang et al., Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains, Medchemcomm, vol.9, pp.1698-1707, 2018.