HPV vaccination in a context of public mistrust and uncertainty: a systematic literature review of determinants of HPV vaccine hesitancy in Europe

Emilie Karafillakis (1) , Clarissa Simas (1) , Caitlin Jarrett , Pierre Verger (2, 3, 4) , Patrick Peretti-Watel (3, 4) , Fadia Dib (5) , Stefania de Angelis (6) , Judit Takacs (7) , Karam Adel Ali (6) , Lucia Pastore Celentano (6) , Heidi Larson (1)

1 LSHTM - London School of Hygiene and Tropical Medicine
2 ORS PACA
3 VITROME - Vecteurs - Infections tropicales et méditerranéennes
4 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
5 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
6 ECDC - European Centre for Disease Prevention and Control [Stockholm, Sweden]
7 MTA - Hungarian Academy of Sciences

Europe is increasingly described as the region in the world with the least confidence in vaccination, and particularly in the safety of vaccines. The aim of this systematic literature review was to gather and summarise all peer-reviewed and grey literature published about determinants of Human Papillomavirus (HPV) vaccine hesitancy in Europe. Ten thematic categories were identified across the 103 articles which were included in the review. Participants from European studies most commonly reported issues with the quantity and quality of information available about HPV vaccination; followed by concerns about potential side effects of the vaccine; and mistrust of health authorities, healthcare workers, and new vaccines. Comparative analyses indicated that confidence determinants differed by country and population groups. This evidence supports the need to develop context-specific interventions to improve confidence in HPV vaccination and design community engagement strategies aiming to build public trust. ARTICLE HISTORY

Mots clés: HPV; HPV vaccination; cervical cancer; vaccine hesitancy; vaccine confidence vaccination

Domaines: Bactériologie; Virologie; Parasitologie; Cardiologie et système cardiovasculaire; Maladies émergentes; Maladies infectieuses

Emilie Karafillakis, Clarissa Simas, Caitlin Jarrett, Pierre Verger, Patrick Peretti-Watel, et al.. HPV vaccination in a context of public mistrust and uncertainty: a systematic literature review of determinants of HPV vaccine hesitancy in Europe. Human Vaccines & Immunotherapeutics, 2019, 15 (7-8), pp.1615-1627. ⟨10.1080/21645515.2018.1564436⟩. ⟨hal-02263706⟩