Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Orchestration of algal metabolism by protein disorder

Abstract : Intrinsically disordered proteins (IDPs) are proteins that provide many functional advantages in a large number of metabolic and signalling pathways. Because of their high flexibility that endows them with pressure-, heat- and acid-resistance, IDPs are valuable metabolic regulators that help algae to cope with extreme conditions of pH, temperature, pressure and light. They have, however, been overlooked in these organisms. In this review, we present some well-known algal IDPs, including the conditionally disordered CP12, a protein involved in the regulation of CO2 assimilation, as probably the best known example, whose disorder content is strongly dependent on the redox conditions, and the essential pyrenoid component 1 that serves as a scaffold for ribulose-1, 5-bisphosphate carboxylase/oxygenase. We also describe how some enzymes are regulated by protein regions, called intrinsically disordered regions (IDRs), such as ribulose-1, 5-bisphosphate carboxylase/oxygenase activase, the A2B2 form of glyceraldehyde-3-phosphate dehydrogenase and the adenylate kinase. Several molecular chaperones, which are crucial for cell proteostasis, also display significant disorder propensities such as the algal heat shock proteins HSP33, HSP70 and HSP90. This review confirms the wide distribution of IDPs in algae but highlights that further studies are needed to uncover their full role in orchestrating algal metabolism.
Complete list of metadata

Cited literature [157 references]  Display  Hide  Download
Contributor : LAURE AZZOPARDI Connect in order to contact the contributor
Submitted on : Wednesday, May 6, 2020 - 5:07:24 PM
Last modification on : Wednesday, November 3, 2021 - 5:49:22 AM


YABBI_2019_431_Original_V0 SUB...
Files produced by the author(s)




Helene Launay, Véronique Receveur-Bréchot, Frédéric Carriere, Brigitte Gontero. Orchestration of algal metabolism by protein disorder. Archives of Biochemistry and Biophysics, Elsevier, 2019, 672, pp.108070. ⟨10.1016/⟩. ⟨hal-02266032⟩



Record views


Files downloads