Journal articles
Clinical and economic burden of head and neck cancer : a nationwide retrospective cohort study from France
Abstract : Objectives:
To evaluate the clinical and economic burden of head and neck squamous cell carcinoma (HNSCC) in France.
Methods:
All 53,255 incident adult patients discharged with a first diagnosis of HNSCC in 2010–2012 were identified from the 2008–2013 French National Hospital Discharge (PMSI) database. We conducted a retrospective longitudinal analysis of prognosis and direct costs attributable to HNSCC.
Results:
Direct medical costs attributable to HNSCC care amounted to 665 million euros in 2012 in France. The majority (62%) of incident patients were 64 years old or less at HNSCC diagnosis and incurred 1.3-fold higher mean direct costs as compared to elderly patients (41,909 vs 32,221 euros over 3 years, respectively; p<0.001). HNSCC stage at initial treatment was the major driver of mean (SD) direct costs over 3 years (p<0.001): 19,819 (23,150) euros in 31% patients diagnosed at early stage; 46,791 (34,841) euros in 60% patients diagnosed at locally advanced stage; and 43,377 (33,953) euros in 9% patients diagnosed with distant metastasis. About half patients died over 3 years at a median (IQR) age of 63 (56–75) years resulting in 10.9 years-of-life lost on average per incident patient.
Conclusion:
The present study suggests that the clinical and economic burden of HNSCC is substantial in France.
Cited literature [43 references]
https://hal-amu.archives-ouvertes.fr/hal-02271446
Contributor : Elisabeth Lhuillier <>
Submitted on : Tuesday, August 27, 2019 - 10:45:35 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:43 AM
Long-term archiving on: : Friday, January 10, 2020 - 6:41:39 AM
Contributor : Elisabeth Lhuillier <>
Submitted on : Tuesday, August 27, 2019 - 10:45:35 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:43 AM
Long-term archiving on: : Friday, January 10, 2020 - 6:41:39 AM
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