Skip to Main content Skip to Navigation
Journal articles

In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles.

Abstract : Capable of generating plasmonic and other effects, gold nanostructures can offer a variety of diagnostic and therapy functionalities for biomedical applications, but conventional chemically-synthesized Au nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au nanoparticles (Aunp) present a viable alternative to chemical counterparts and can offer exceptional purity (no trace of contaminants) and unusual surface chemistry making possible direct conjugation with biocompatible polymers (dextran, polyethylene glycol). this work presents the first pharmacokinetics, biodistribution and safety study of laser-ablated dextran-coated Aunp (Aunpd) under intravenous administration in small animal model. our data show that Aunpd are rapidly eliminated from the blood circulation and accumulated preferentially in liver and spleen, without inducing liver or kidney toxicity, as confirmed by the plasmatic ALAT and ASAT activities, and creatininemia values. Despite certain residual accumulation in tissues, we did not detect any sign of histological damage or inflammation in tissues, while IL-6 level confirmed the absence of any chronic inflammation. The safety of AuNPd was confirmed by healthy behavior of animals and the absence of acute and chronic toxicities in liver, spleen and kidneys. our results demonstrate that laser-synthesized Aunp are safe for biological systems, which promises their successful biomedical applications.
Complete list of metadata
Contributor : David Bergé-Lefranc Connect in order to contact the contributor
Submitted on : Wednesday, January 6, 2021 - 2:58:55 PM
Last modification on : Wednesday, November 3, 2021 - 9:56:33 AM


Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License



Anne-Laure Bailly, Florian Correard, Popov Anton, Gleb Tselikov, Florence Chaspoul, et al.. In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles.. Scientific Reports, Nature Publishing Group, 2019, 9, pp.12890. ⟨10.1038/s41598-019-48748-3⟩. ⟨hal-02296834⟩



Les métriques sont temporairement indisponibles