, Recrystallization of this material from dichloromethane gave monocrystalline prisms suitable for X-ray diffraction analysis. [7] R f (EtOAc/DCM, 4:6) = 0.15. Mp 217.0-219.0°C. HRMS (ESI+): [M+H] + calcd. for C 14 H 15 N 2 O + 227.1179, found 227, 1177.

C. Nmr, C), 148.2 (C, vol.128, pp.129-130

, 49 mL) was added 10 % Pd/C (104 mg) and the solution was placed under an atmosphere of hydrogen with vigorous stirring for four days at room temperature. The resulting suspension was filtered through celite, concentrated in vacuo and purified by flash chromatography eluted with EtOAc/PE, 6:4 to afford pure 1f (230 mg, 85 %) as a colorless oil, To a solution of 10f Bn (380 mg, 1.05 mmol) in methanol, vol.1

, 78 (dd, J = 8.6, 2.4 Hz, 1H), 6.40 (broad s, 1H), 5.22 (s, 1H), 3.79-3.68 (m, 2H), 3.23 (s, 3H), 3.12 (s, 3H, methanesulfonate salt 1f·TfOH: Mp 238-239°C. 1 H NMR (300 MHz, ? ppm/C 6 D 6 ): 7.77 (d, J = 8.5 Hz, 1H), vol.6, pp.56-62

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