The SUF system: an ABC ATPase-dependent protein complex with a role in Fe–S cluster biogenesis

Pierre Simon Garcia (1, 2) , Simonetta Gribaldo (2) , Beatrice Py (3) , Frédéric Barras (1)

1 Adaptation au stress et métabolisme chez les entérobactéries - Stress adaptation and metabolism in enterobacteria
2 Biologie Evolutive de la Cellule Microbienne - Evolutionary Biology of the Microbial Cell
3 LCB - Laboratoire de chimie bactérienne

Iron-sulfur (Fe–S) clusters are considered one of the most ancient and versatile inorganic cofactors present in the three domains of life. Fe–S clusters can act as redox sensors or catalysts and are found to be used by a large number of functional and structurally diverse proteins. Here, we cover current knowledge of the SUF multiprotein machinery that synthesizes and inserts Fe–S clusters into proteins. Specific focus is put on the ABC ATPase SufC, which contributes to building Fe–S clusters, and appeared early on during evolution.

Keywords: Iron-sulfur cluster; Iron-sulfur biogenesis; P-loop ATPase; Suf proteins; SufBCD complex

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Biodiversity; Populations and Evolution [q-bio.PE]

Pierre Simon Garcia, Simonetta Gribaldo, Beatrice Py, Frédéric Barras. The SUF system: an ABC ATPase-dependent protein complex with a role in Fe–S cluster biogenesis. Research in Microbiology, 2019, pp.S0923-2508(19)30085-3. ⟨10.1016/j.resmic.2019.08.001⟩. ⟨hal-02376694⟩