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Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities

Abstract : Some new β-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino β-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC 50 values.
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https://hal-amu.archives-ouvertes.fr/hal-02391762
Contributor : Jean Michel Brunel <>
Submitted on : Tuesday, December 3, 2019 - 4:44:27 PM
Last modification on : Saturday, May 30, 2020 - 3:36:55 AM
Long-term archiving on: : Wednesday, March 4, 2020 - 4:34:10 PM

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Oxana Kazakova, Jean Michel Brunel, Elmira Khusnutdinova, Sophie Negrel, Gulnara Giniyatullina, et al.. Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities. Molbank, MDPI, 2019, 2019 (3), pp.M1078. ⟨10.3390/M1078⟩. ⟨hal-02391762v1⟩

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