, > 250 °C; IR (ATR) v max 3241, vol.8, p.76, 1239.
, 2H, d, J = 1.3 Hz, H-7, H-7?), 7.39 (2H, dd, J = 8.5, 1.3 Hz, H-5, H-5?), vol.3
C-3a, C-3a?), C-4?), vol.125, pp.38-40 ,
, , vol.26
, Dodecane-1,12-diyl)bis(2-(6-bromo-1H-indol-3-yl)-2-oxoacetamide
, 077 g, 0.286 mmol) was reacted with 1,12-diaminododecane (0.029 g, 0.143 mmol), pp.17-28
C-7a, C-7a?), 125.3 (C-5, C-5?), 125.2 (C-3a, C-3a?, 400 MHz) ? 12.26 (2H, br s, NH-1, NH-1?), 8.75 (2H, s, H-2, H-2?), 8.70 (2H, t, J = 5.9 Hz, NH-10, NH-10?), 8.14 (2H, d, J = 8.5 Hz, H-4, H-4?), 7.73 (2H, d, J = 1.0 Hz, H-7, H-7?), 7.39 (2H, dd, J = 8.5, 1.0 Hz, H-5, H-5?), 3.22-3.15 (4H, m, H 2 -11, H 2 -11?, vol.3234, pp.799-800, 1128. ,
, Oxybis(ethane-2,1-diyl))bis(oxy))bis(propane-3,1-diyl)) bis(2-(6-bromo-1H-indol-3-yl
, Following the general procedure, 278 mmol) was reacted with 4, vol.7, pp.10-11
400 MHz) ? 12.23 (2H, br s, NH-1, NH-1?), 8.76 (2H, s, H-2, H-2?), 8.71 (2H, t, J = 5.9 Hz, vol.742, pp.659-660, 1107. ,
, 4H, m, H 2 -12, H 2 -12?); 13 C NMR (DMSOd 6 , 100 MHz) ? 182.3 (C-8, C-8?, vol.163
, 68.3 (C-13, C-13?), vol.36
, 296 mmol) was reacted with N,N-dimethylethylenediamine (0.032 mL, 0.296 mmol), PyBOP (0.154 g, 0.296 mmol) and triethylamine (0.124 mL, 0.887 mmol) in DMF for 24 h. Purification by diol-bonded silica gel column chromatography (CH 2 Cl 2 /3% MeOH), pp.17-28
, ) 0.11; m.p. 209.1-210.5 °C; IR (ATR) v max 3345, vol.9, pp.681-682, 1231.
, H-4), 7.73 (1H, d, J = 1.8 Hz, H-7), vol.7, p.100
, 139.4 (C-2), 137.2 (C-7a), 125.4 (C-5), 125.2 (C-3a), vol.182, pp.163-163
, Following the general procedure, 17 11 (0.071 g, 0.263 mmol) was reacted with 2-morpholinoethylamine
, PyBOP (0.137 g, 0.263 mmol) and triethylamine (0.110 mL, 0.789 mmol) in DMF for 24 h. Purification by diol-bonded silica gel column chromatography (CH 2 Cl 2 /3% MeOH)
, IR (ATR) v max 3304, vol.3255, pp.661-662, 1110.
, 7.87 (1H, t, J = 5.0 Hz, NH-10), 7.60 (1H, d, J = 1.6 Hz, H-7), vol.7
, Strains were maintained at -80 °C in 15% (v/v) glycerol for cryoprotection, S. aureus (ATCC25923), S. intermedius (1051997), E. coli (ATCC25922) and P. aeruginosa (ATCC27853 and PAO1)
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