, Compounds 5c, 5h, and 5q-t were examined for their anticancer properties against K562 Leukemia cell line and 5s showed the best activity. Compounds 3a-j, 5a-o, 5h, 6a and 6c showed IC 50 < 20 µM while 5b, 5c, 5e, 5f, 5g, 5i, 5j, 6d, 6g and 6h exhibited IC 50 < 50, p.10261

S. Kar and S. Kar, Control of malaria, Nat. Rev. Drug Discov, vol.9, pp.511-513, 2010.

E. Aviles and A. D. Rodriguez, Monamphilectine A, a Potent Antimalarial ?-Lactam from Marine Sponge Hymeniacidon sp: Isolation, Structure, Semisynthesis, and Bioactivity Org. Lett, vol.12, pp.5290-5293, 2010.

R. G. Ridley, Planting the seeds of new antimalarial drugs, Science, vol.285, pp.1502-150, 1999.

W. Peters, Chemotherapy and Drug Resistance in Malaria, vol.2, 1987.

A. Jarrahpour, E. Ebrahimi, D. Clercq, E. Sinou, V. Latour et al., Synthesis of mono-, bis-spiro-and dispiro-b-lactams and evaluation of their antimalarial activities, Tetrahedron, vol.67, pp.8699-704, 2011.

M. Nivsarkar, D. Thavaselvam, S. Prasanna, and M. Sharma, Synthesis Evaluation of Novel Bicyclic ?-Lactams as Potential Antimalarials, Bioorg. Med. Chem. Lett, vol.15, pp.1371-1374, 2005.

A. Jarrahpour and M. Zarei, Efficient one-pot synthesis of 2-azetidinones from acetic acid derivatives and imines using methoxymethylene-N, N-dimethyliminium salt, Tetrahedron, vol.66, pp.5017-5040, 2010.

C. Palomo, J. M. Aizpurua, I. Ganboa, and M. Oiarbide, Asymmetric synthesis of ?-lactams through the staudinger reaction and their use as building blocks of natural and nonnatural products, Curr. Med. Chem, vol.11, pp.1837-72, 2004.

G. Dr and M. Koketsu, Synthesis of seleniumcontaining bicyclic beta-lactams via alkene metathesis, Org. Biomol. Chem, vol.7, pp.2591-2599, 2009.

M. O&apos;driscoll, K. Greenhalgh, A. Young, E. Turos, D. S. Lim et al., Studies on the antifungal properties of N-thiolated beta-lactams, Bioorg. Med. Chem, vol.16, pp.7832-7839, 2008.

Z. Jarrahpour and A. , Synthesis of N-unsubstituted ?-lactams from N-alkoxyphenyl-?-lactams with cobalt(III) fluoride, Tetrahedron.Lett, vol.51, pp.5791-5795, 2010.

B. Alcaide, A. , P. , and R. Mc, N 1 -C 4 ?-Lactam Bond Cleavage in the 2-(Trimethylsilyl) thiazole Addition to ?-Lactam Aldehydes: Asymmetric Synthesis of Spiranic and Tertiary ?-Alkoxy-?-keto Acid Derivatives, Eur. J. Org. Chem, pp.3707-3710, 2007.

H. Staudinger, Liebigs Ann. Chem, vol.356, pp.51-123, 1907.

P. A. Krapcho and C. S. Kuell, Mono-protected diamines-N-tert-butoxycarbonyl-alpha,omegaalkanediaminesman from alpha,omega-alkanediamine, Synth. Commun, vol.20, pp.2559-64, 1990.

W. Trager and J. B. Jensen, Human malaria parasites in continuous culture, Science, vol.193, pp.673-678, 1976.

C. Lambros and J. P. Vanderberg, Synchronization of Plasmodium falciparum erythrocytic stages in culture, J. Parasitol, vol.65, pp.418-438, 1979.

G. Gi and V. T. Ravikumar, The Organic Chemistry of ?-lactams, p.295, 1993.

M. Akkurt, D. Y?lmaz, A. Jarrahpour, M. Rostami, and O. Buyukgungor, 1-(4-Methoxyphenyl)-4 -(4-methylphenyl)-3-phenoxyazetidin-2-one, Acta Cryst. Sec. E, vol.67, pp.326-333, 2011.