J. R. Morphy and Z. Rankovic, The physicochemical challenges of designing multiple ligands, J. Med. Chem, vol.49, pp.4961-4970, 2006.

F. W. Muregi and A. Ishih, Next-generation antimalarial drugs: hybrid molecules as a new strategy in drug design, Drug. Dev. Res, vol.71, pp.20-32, 2010.

R. Raj, V. Sharma, M. J. Hopper, N. Patel, D. Hall et al., Synthesis and preliminary in vitro activity of mono-and bis-1H-1,2,3-triazole-tethered ?-lactamisatin conjugates against the human protozoal pathogen Trichomonas vaginalis, Med. Chem. Res, vol.23, pp.3671-3680, 2014.

B. Meunier, Hybrid molecules with a dual mode of action: dream or reality?, Acc. Chem. Res, vol.41, pp.69-77, 2008.

R. Fareghi-alamdari, N. Zekri, and F. Mansouri, Enhancement of catalytic activity in the synthesis of 2-amino-4H-chromene derivatives using both copper-and cobalt-incorporated magnetic ferrite nanoparticles, Res. Chem. Intermed, vol.43, pp.6537-6551, 2017.

W. H. Dos-santos and L. D. Da-silva-filho, New method for the synthesis of chromeno[4,3-b]chromene derivatives via multicomponent reaction promoted by niobium pentachloride, Tetrahedron Lett, vol.58, pp.894-897, 2017.

R. Pratap and V. J. Ram, Natural and synthetic chromenes, fused chromenes, and versatility of dihydrobenzo[h]chromenes in organic synthesis, Chem. Rev, vol.114, pp.10476-10526, 2014.

J. A. Tanna, R. Gomaji-chaudharya, N. Gandharec, A. R. Rai, S. Yerpuded et al., Copper nanoparticles catalysed an efficient one-pot multicomponents synthesis of chromenes derivatives and its antibacterial activity, J. Exp. Nano. Sci, vol.11, pp.884-900, 2016.

N. Sabry, H. M. Mohamed, E. Sh, S. S. Khattab, A. M. Motlaq et al., Synthesis of 4H-chromene, coumarin, 12H-chromeno[2,3-d]pyrimidine derivatives and some of their antimicrobial and cytotoxicity activities, Eur. J. Med. Chem, vol.46, pp.765-772, 2011.

S. Banerjee, J. Wang, S. Pfeffer, D. Ma, L. Pfeffer et al., Design, synthesis and biological evaluation of novel 5H-chromenopyridines as potential anti-cancer agents, Molecules, vol.20, pp.17152-17165, 2015.

G. Zhang, Y. Zhang, J. Yan, R. Chen, S. Wang et al., One-pot enantioselective synthesis of functionalized pyranocoumarins and 2-amino-4H-chromenes: discovery of a type of potent antibacterial agent, J. Org. Chem, vol.77, pp.878-888, 2012.

J. Rad, A. Jarrahpour, C. C. Ersanl?, Z. Atioglu, M. Akkurt et al., Synthesis of some novel indeno[1,2-b]quinoxalin spiro-?-lactam conjugates, Tetrahedron, vol.73, pp.1135-1142, 2017.

S. Vandekerckhove and M. , Exploration of aziridine and ?-lactam-based hybrids as both bioactive substances and synthetic intermediates in medicinal chemistry, Bioorg. Med. Chem, vol.21, pp.3643-3647, 2013.

T. Sperka, J. Pitlik, P. Bagossi, and J. , Tozsér, ?-Lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease, Bioorg. Med. Chem. Lett, vol.15, pp.3086-3090, 2005.

A. Jarrahpour, S. Rezaei, V. Sinou, C. Latour, and J. M. Brunel, Synthesis of some novel 3-spiro monocyclic ?-lactams and their antibacterial and antifungal investigations, Iran. J. Sci. Technol.Trans. A: Science, vol.41, pp.337-342, 2017.

B. K. Banik, I. Banik, and F. F. Becker, Asymmetric synthesis of anticancer ?-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate, Eur. J. Med. Chem, vol.45, pp.846-848, 2010.

N. M. O'boyle, M. Carr, L. M. Greene, O. Bergin, S. M. Nathwani et al., Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents, J. Med. Chem, vol.53, pp.8569-8584, 2010.

M. Alborz, A. Jarrahpour, R. Pournejati, H. Karbalaei-heidari, V. Sinou et al.,

H. Brunel, M. Sharghi, E. Aberi, L. Turos, and . Wojtas, Synthesis and biological evaluation of some novel diastereoselective benzothiazole ?-lactam conjugates, Eur. J. Med. Chem, vol.143, pp.283-291, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02143539

B. Indrani, F. B. Fredrick, and K. B. Bimal, Microwave-induced synthesis of enantiopure ?lactams, Mod. Chem. Appl, vol.5, pp.2329-6798, 2017.

N. Borazjani, A. Jarrahpour, J. Rad, M. Mohkam, M. Behzadi et al., Turos, Design, synthesis and biological evaluation of some novel diastereoselective ?-lactams bearing 2-mercaptobenzothiazole and benzoquinoline, Med. Chem. Res, vol.28, pp.329-339, 2019.

S. P. Westrip, publCIF: software for editing, validating and formatting crystallographic information files, J. Appl. Cryst, vol.43, pp.920-925, 2010.

B. Baghernejad, ]octane (DABCO) as a useful catalyst in organic synthesis, Eur. J. Chem, vol.1, pp.54-60, 2010.

J. Wu, X. Sun, and Y. Li, DABCO: An efficient organocatalyst in the ring-opening reactions of aziridines with amines or thiols, Eur. J. Org. Chem, vol.20, pp.4271-4275, 2005.

N. Razzaghi-asl, S. Mirzayi, K. Mahnam, and S. Sepehri, Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation, J. Mol. Graph. Model, vol.83, pp.138-152, 2018.

J. N. Sharma, A. Al-omran, and S. S. Parvathy, Role of nitric oxide in inflammatory diseases, Inflammopharmacology, vol.15, pp.252-259, 2007.