6IMEP - Institut Méditerranéen d'Ecologie et de Paléoécologie (Europole de l'Arbois BP 80 13545 Aix-en-Provence cedex 04 Faculté des Sciences de St Jérôme Av. Escadrille Normandie-Niemen - Boite 441 13397 Marseille cedex 20 Faculté des Sciences St Charles 3 place Victor Hugo 13331 Marseille cedex 03 - France)
Abstract : Chemosensory systems are highly organized signaling pathways that allow bacteria to adapt to environmental changes. The Frz chemosensory system from M. xanthus possesses two CheW-like proteins, FrzA (the core CheW) and FrzB. We found that FrzB does not interact with FrzE (the cognate CheA) as it lacks the amino acid region responsible for this interaction. FrzB, instead, acts upstream of FrzCD in the regulation of M. xanthus chemotaxis behaviors and activates the Frz pathway by allowing the formation and distribution of multiple chemosensory clusters on the nucleoid. These results, together, show that the lack of the CheA-interacting region in FrzB confers new functions to this small protein.
https://hal-amu.archives-ouvertes.fr/hal-02423614 Contributor : Tam MignotConnect in order to contact the contributor Submitted on : Monday, January 6, 2020 - 4:01:50 PM Last modification on : Friday, August 5, 2022 - 10:56:56 AM Long-term archiving on: : Tuesday, April 7, 2020 - 11:00:11 PM
Annick Guiseppi, Juan Jesus Vicente, Julien Herrou, Deborah N Byrne, Aurelie Barneoud, et al.. A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays. PLoS Genetics, Public Library of Science, 2019, 15 (12), pp.e1008533. ⟨10.1371/journal.pgen.1008533⟩. ⟨hal-02423614⟩