A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays - Archive ouverte HAL Access content directly
Journal Articles PLoS Genetics Year : 2019

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

Abstract

Chemosensory systems are highly organized signaling pathways that allow bacteria to adapt to environmental changes. The Frz chemosensory system from M. xanthus possesses two CheW-like proteins, FrzA (the core CheW) and FrzB. We found that FrzB does not interact with FrzE (the cognate CheA) as it lacks the amino acid region responsible for this interaction. FrzB, instead, acts upstream of FrzCD in the regulation of M. xanthus chemotaxis behaviors and activates the Frz pathway by allowing the formation and distribution of multiple chemosensory clusters on the nucleoid. These results, together, show that the lack of the CheA-interacting region in FrzB confers new functions to this small protein.
Fichier principal
Vignette du fichier
journal.pgen.1008533.pdf (9.7 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

hal-02423614 , version 1 (06-01-2020)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Annick Guiseppi, Juan Jesus Vicente, Julien Herrou, Deborah N Byrne, Aurelie Barneoud, et al.. A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays. PLoS Genetics, 2019, 15 (12), pp.e1008533. ⟨10.1371/journal.pgen.1008533⟩. ⟨hal-02423614⟩
126 View
69 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More