Skip to Main content Skip to Navigation
Journal articles

Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

Abstract : In area CA1 of the hippocampus, the selection of place cells to represent a new environment is biased towards neurons with higher excitability. However, different environments are represented by orthogonal cell ensembles, suggesting that regulatory mechanisms exist. Activity-dependent plasticity of intrinsic excitability, as observed in vitro, is an attractive candidate. Here, using whole-cell patch-clamp recordings of CA1 pyramidal neurons in anesthetized rats, we have examined how inducing theta-bursts of action potentials affects their intrinsic excitability over time. We observed a long-lasting, homeostatic depression of intrinsic excitability which commenced within minutes, and, in contrast to in vitro observations, was not mediated by dendritic Ih. Instead, it was attenuated by the Kv1.1 channel blocker dendrotoxin K, suggesting an axonal origin. Analysis of place cells' out-of-field firing in mice navigating in virtual reality further revealed an experience-dependent reduction consistent with decreased excitability. We propose that this mechanism could reduce memory interference.
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-02437688
Contributor : Christophe Pellegrino <>
Submitted on : Monday, January 13, 2020 - 8:41:20 PM
Last modification on : Tuesday, February 4, 2020 - 10:00:04 AM

Links full text

Identifiers

Collections

Citation

Peter James Morgan, Romain Bourboulou, Caroline Filippi, Julie Koenig-Gambini, Jérôme Epsztein. Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo. eLife, eLife Sciences Publication, 2019, 8, pii: e49915. ⟨10.7554/eLife.49915⟩. ⟨hal-02437688⟩

Share

Metrics

Record views

83