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Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis

Abstract : Graphical Abstract Highlights d 250 Mesp1 progenitors give rise to all cardiomyocytes d Mesp1 progenitors present distinct regional mode of growth d Mesp1 progenitors present similar clonal dynamics Correspondence bds10@cam.ac.uk (B.D.S.), cedric.blanpain@ulb.ac.be (C.B.) In Brief Chabab et al. show that about 250 Mesp1 cardiac progenitors specified during gastrulation contribute to heart myocardium morphogenesis. Distinct subpopulations of Mesp1 progenitors, emerging at different time points during development and leading to the formation of different regions of the heart, share similar proliferative capacities.
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Samira Chabab, Fabienne Lescroart, Steffen Rulands, Navrita Mathiah, Benjamin d. Simons, et al.. Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis. Cell Reports, Elsevier Inc, 2016, 14 (1), pp.1-10. ⟨10.1016/j.celrep.2015.12.013⟩. ⟨hal-02441138⟩

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