V. Adler, Z. Yin, T. Kd, and Z. Ronai, Role of redox potential and reactive oxygen species in stress signaling, Oncogene, vol.18, pp.6104-6111, 1999.

V. V. Arkhipchuk, C. Blaise, and M. V. Malinovskaya, Use of hydra for chronic toxicity assessment of waters intended for human consumption, Environ. Pollut, vol.142, pp.200-211, 2006.

L. Arnaud, N. Baran, and L. Gourcy, Etude du transfert de la chlordécone vers les eaux souterraines en Martinique, Rapport BRGM/RP-61767-FR. 73p, vol.49, 2013.

S. Bonello, C. Zähringer, R. S. Belaiba, T. Djordjevic, J. Hess et al., , 2007.

, Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site, Arterioscler Thromb Vasc Biol, vol.27, issue.4, pp.755-61

O. Boucher, M. Simard, G. Muckle, F. Rouget, P. Kadhel et al., Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants, Neurotoxicology, vol.35, pp.162-170, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00875907

Y. Cabidoche, R. Achard, P. Cattan, C. Clermont-dauphin, F. Massat et al., Long-term pollution by chlordecone of tropical volcanic soils in the FrenchWest Indies: a simple leaching model accounts for current residue, Environ Pollut, vol.157, pp.1697-705, 2009.

S. Coat, D. Monti, P. Legendre, C. Bouchon, F. Massat et al., Organochlorine pollution in tropical rivers (Guadeloupe): role of ecological factors in food web bioaccumulation, Environ Pollut, vol.159, pp.1692-701, 2011.

R. B. Conolly and W. K. Lutz, Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment, Toxicol. Sci. Off. J. Soc. Toxicol, vol.77, pp.151-157, 2004.

R. Dallaire, G. Muckle, F. Rouget, P. Kadhel, H. Bataille et al., Cognitive, visual, and motor development of 7-monthold Guadeloupean infants exposed to chlordecone, Environ Res, vol.118, pp.79-85, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00875939

L. De-jong, N. Pech, G. De-aragão-umbuzeiro, and X. Moreau, Multi-scale biomarker evaluation of the toxicity of a commercial azo dye (Disperse Red 1) in an animal model, the freshwater cnidarian Hydra attenuata, Water Res, vol.96, pp.62-73, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01452189

C. Dubuisson, F. Héraud, J. Leblanc, S. Gallotti, C. Flamand et al., Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone, Regul Toxicol Pharmacol, vol.49, pp.5-16, 2007.
URL : https://hal.archives-ouvertes.fr/anses-01875185

R. Eggen, R. Behra, P. Burkhardt-holm, B. I. Escher, and N. Schweigert, Challenges in ecotoxicology, 2004.

, Environ Sci Technol, vol.38, issue.3, pp.58-64

B. Galliot, Hydra, a fruitful model system for 270 years, Int J Dev Biol, vol.56, pp.411-423, 2012.

B. Galliot, Regeneration in Hydra, 2013.

A. C. Gore, V. A. Chappell, S. E. Fenton, J. A. Flaws, A. Nadal et al., EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals, Endocr Rev, vol.36, issue.6, pp.1-150, 2015.

L. N. Gourcy and B. Vittecoq, Improving the knowledge of pesticide and nitrate transfer processes using agedating tools (CFC, SF6, 3H) in a volcanic island, Journal of Contaminant Hydrology, vol.108, issue.3-4, pp.107-117, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00515327

L. Guldner, L. Multigner, F. Héraud, C. Monfort, J. Thomé et al., Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone, Environ Res, vol.110, pp.146-51, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00517109

A. Hershko and A. Ciechanover, The ubiquitin system, Annu Rev Biochem, vol.67, pp.425-79, 1998.

L. Hou, X. Zhang, D. Wang, and A. Baccarelli, Environmental chemical exposures and human epigenetics, 2012.

, Int J Epidemiol, vol.41, issue.1, pp.79-105

P. E. Jablonski, D. J. Pheasant, and J. G. Ferry, Conversion of kepone by Methanosarcina thermophila, FEMS Microbiol Lett, vol.139, pp.137-138, 1996.

D. R. Kashian, Toxaphene detoxification and acclimation in Daphnia magna: do cytochrome P-450 enzymes play a role? Comp, Biochem. Physiol. Toxicol. Pharmacol. CBP, vol.137, pp.53-63, 2004.

S. Knerr, J. Schaefer, S. Both, A. Mally, W. Dekant et al., 8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells, Mol. Nutr. Food Res, vol.2, pp.378-384, 2006.

M. Lu and A. , CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies, Drug Metab. Dispos. Biol. Fate Chem, vol.35, pp.1009-1016, 2007.

C. Mottes, L. Jannoyer, M. , L. Bail, M. Guéné et al., Relationships between past and present pesticide applications and pollution at a watershed outlet: The case of a horticultural catchment in Martinique, French West Indies. Chemosphere, vol.184, pp.762-773, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01637738

M. De and D. Bridge, Hydra, the everlasting embryo, confronts aging, Int J Dev Biol, vol.56, issue.6-8, pp.479-87, 2012.

L. Multigner, J. R. Ndong, A. Giusti, M. Romana, H. Delacroix-maillard et al., Chlordecone exposure and risk of prostate cancer, J Clin Oncol, vol.28, pp.3457-62, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00518099

D. R. Nelson, L. Koymans, T. Kamataki, J. J. Stegeman, R. Feyereisen et al., superfamily: update on new sequences, gene mapping, accession numbers and nomenclature, Pharmacogenetics, vol.6, issue.1, pp.1-42, 1996.

S. Nóbrega-pereira, P. J. Fernandez-marcos, T. Brioche, M. C. Gomez-cabrera, A. Salvador-pascual et al., G6PD protects from oxidative damage and improves healthspan in mice, Nat Commun, vol.7, p.10894, 2016.

N. Arnér and E. S. , Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic, Biol. Med, vol.31, pp.1287-1312, 2001.

S. Pachura-bouchet, C. Blaise, and P. Vasseur, Toxicity of nonylphenol on the cnidarian Hydra attenuata and environmental risk assessment, Environ Toxicol, vol.21, issue.4, pp.388-94, 2006.

B. Quinn, F. Gagné, and C. Blaise, Hydra, a model system for environmental studies, Int J Dev Biol, vol.56, pp.613-625, 2012.

L. Reed, V. M. Arlt, and D. H. Phillips, The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo -in vitro paradox, Carcinogenesis, vol.39, issue.7, pp.851-859, 2018.

T. D. Schmittgen and K. J. Livak, Analyzing real-time PCR data by the comparative C(T) method, Nat Protoc, vol.3, issue.6, pp.1101-1109, 2008.

H. U. Simon, A. Haj-yehia, and F. Levi-schaffer, Role of reactive oxygen species (ROS) in apoptosis induction, Apoptosis, vol.5, issue.5, pp.415-423, 2000.

Y. Song, W. S. Wu, M. Gao, P. Song, J. Lou et al., Transgenerational impaired male fertility with an Igf2 epigenetic defect in the rat are induced by the endocrine disruptor p, Hum Reprod, vol.29, issue.11, pp.2512-2533, 2014.

T. Takahashi, O. Koizumi, Y. Ariura, A. Romanovitch, T. C. Bosch et al.,

M. Hatta and T. Fujisawa, A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra, Development, vol.127, issue.5, pp.997-1005, 2000.

S. Trottier, C. Blaise, T. Kusui, and E. M. Johnson, Acute toxicity assessment of aqueous samples using a microplate-based Hydra attenuata assay, Environ. Toxicol. Water Qual, vol.12, pp.265-271, 1997.

L. N. Vandenberg, T. Colborn, T. B. Hayes, J. J. Heindel, D. R. Jacobs et al., Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses, Endocr Rev, vol.33, issue.3, pp.378-455, 2012.

E. A. Veal, W. M. Toone, N. Jones, and B. A. Morgan, Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe, J Biol Chem, vol.277, issue.38, pp.35523-35554, 2002.

P. H. Villard, E. M. Seree, J. L. Re, D. Meo, M. Barra et al., Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: relation to single strand breaks of DNA, Toxicol Appl Pharmacol, vol.148, issue.2, pp.195-204, 1998.

S. Woo, A. Lee, H. Won, J. C. Ryu, and S. Yum, Toxaphene affects the levels of mRNA transcripts that encode antioxidant enzymes in Hydra, Comp Biochem Physiol C Toxicol Pharmacol, vol.156, issue.1, pp.37-41, 2012.

S. Woo, S. Yum, D. W. Kim, and H. S. Park, Transcripts level responses in a marine medaka (Oryzias javanicus) exposed to organophosphorus pesticide, Comp Biochem Physiol C Toxicol Pharmacol, vol.149, issue.3, pp.427-459, 2009.

H. Y. Yu, Y. Guo, and E. Y. Zeng, Dietary intake of persistent organic pollutants and potential health risks via consumption of global aquatic products, Environ Toxicol Chem, vol.29, issue.10, pp.2135-2177, 2010.

, GPx Forward 5'-TCGATATCTGGAACCAATGACAAA-3' Reverse 5'-CGAGGCGCCCACTATGACTT-3'

, CYP1A Forward 5'-GCTGGCGATCATGTTGCTGTTT-3' Reverse 5'-AGTTTCTGCTGTAGTGTATTGA-3'

, AChe Forward 5'-GGTTATAGTCCTGACAGCGAGTTT-3' Reverse 5

, Hym-355 Forward 5'-ATGCCTAACCGGTGATGCT-3' Reverse 5'-TTGCCTCCTCTTGGTAAAAA-3' 54 56 UBI Forward 5'-CACCAGACCAGCAACGACTTAT-3' Reverse 5