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MRI assessment of multiple dipolar relaxation time ( T 1 D ) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model

Abstract : T 1D , the relaxation time of dipolar order, is sensitive to slow motional processes. Thus T 1D is a probe for membrane dynamics and organization that could be used to characterize myelin, the lipid-rich membrane of axonal fibers. A mono-component T 1D model associated with a modified ihMT sequence was previously proposed for in vivo evaluation of T 1D with MRI. However, experiments have suggested that myelinated tissues exhibit multiple T 1D components probably due to a heterogeneous molecular mobility. A bi-component T 1D model is proposed and implemented. ihMT images of ex-vivo, fixed rat spinal cord were acquired with multiple frequency alternation rate. Fits to data yielded two T 1D s of about 500 µs and 10 ms. The proposed model seems to further explore the complexity of myelin organization compared to the previously reported mono-component T 1D model.
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Submitted on : Monday, January 27, 2020 - 12:33:37 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:23 PM

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Victor N.D. Carvalho, Andreea Hertanu, Axelle Grélard, Samira Mchinda, Lucas Soustelle, et al.. MRI assessment of multiple dipolar relaxation time ( T 1 D ) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model. Journal of Magnetic Resonance, Elsevier, 2020, 311, pp.106668. ⟨10.1016/j.jmr.2019.106668⟩. ⟨hal-02456394⟩

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