Journal articles
Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia
Abstract : Background: The etiology of schizophrenia is extensively debated, and multiple factors have been contended to be involved. A panoramic view of the contributing factors in a genome-wide study can be an effective strategy to provide a comprehensive understanding of its causality.
Materials and Methods: GSE53987 dataset downloaded from GEO-database, which comprised mRNA expression data of post-mortem brain tissue across three regions from control (C) and age-matched subjects (T) of schizophrenia (N = Hippocampus [HIP]: C-15, T-18, Prefrontal cortex [PFC]: C-15, T-19, Associative striatum [STR]: C-18, T-18). Bio-conductor—affy—package used to compute mRNA expression, and further t-test applied to investigate differential gene expression. The analysis of the derived genes performed using the PANTHER Classification System and NCBI database. Further, a protein interactome analysis of the derived gene set was performed using STRING v10 database (https://string-db.org/)
Results: A set of 40 genes showed significantly altered (p < 0.01) expression across all three brain regions. The analyses unraveled genes implicated in biological processes and events, and molecular pathways relating basic neuronal functions.
Conclusions: The aberrant expression of genes maintaining basic cell machinery explains compromised neuronal processing in SCZ.
Cited literature [58 references]
https://hal-amu.archives-ouvertes.fr/hal-02458882
Contributor : Lionel Spinelli <>
Submitted on : Wednesday, January 29, 2020 - 8:26:22 AM
Last modification on : Friday, January 31, 2020 - 1:35:36 AM
Long-term archiving on: : Thursday, April 30, 2020 - 12:45:52 PM
Contributor : Lionel Spinelli <>
Submitted on : Wednesday, January 29, 2020 - 8:26:22 AM
Last modification on : Friday, January 31, 2020 - 1:35:36 AM
Long-term archiving on: : Thursday, April 30, 2020 - 12:45:52 PM
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fpsyt-10-00906.pdf
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