Skip to Main content Skip to Navigation
Journal articles

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: results from the national FACE-SZ cohort. Running title: hypovitaminosis D, depression and anxiety in schizophrenia

Guillaume Fond 1, 2, 3 O. Godin 4, 5 F. Schürhoff 4, 6 F. Berna 7, 4 E. Bulzacka 6, 4 M. Andrianarisoa 4, 6 L. Brunel 4, 6 B. Aouizerate 4, 8 D. Capdevielle 4, 9 I. Chereau 4, 7 N Coulon 4, 6 T. d'Amato 10, 4 C. Dubertret 4, 11 J. Dubreucq 4, 12 C. Faget 4, 3 C. Lançon 13, 4, 3 S. Leignier 4, 12 J. Mallet 4, 11 D. Misdrahi 4, 8 C. Passerieux 4, 14 R. Rey 4, 10 A. Schandrin 4, 9 M. Urbach 4, 14 P. Vidailhet 15 M. Leboyer 4, 6 L. Boyer 4, 3 Pm Llorca 7, 4
1 AMU - Aix Marseille Université
2 AP-HM - Assistance Publique-Hôpitaux de Marseille
3 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
4 Fondation FondaMental [Créteil]
5 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
6 Inserm U955 - Molecular virology and immunology – Physiopathology and therapeutic of chronic viral hepatitis (Team 18)
IMRB - Institut Mondor de Recherche Biomédicale
7 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
8 UB - Université de Bordeaux
9 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
10 CRNL - Centre de recherche en neurosciences de Lyon
11 UPD7 - Université Paris Diderot - Paris 7
12 Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère]
13 Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
14 HANDIReSP - Laboratoire de recherches cliniques et en santé publique sur les handicaps psychique, cognitif et moteur
15 UNISTRA - Université de Strasbourg
Abstract : Objective Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors. Methods A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Hypovitaminosis D was defined by blood vitamin D level <25 nM. Depressive symptoms were assessed by the Positive and Negative Syndrome Scale depressive subscore and current anxiety disorder by the Structured Clinical Interview for Mental Disorders. Results Hypovitaminosis D has been found in 21.4% of the subjects and none of them had received vitamin D supplementation in the previous 12 months. In multivariate analysis, hypovitaminosis D has been significantly associated with respectively higher depressive symptoms (aOR = 1.18 [1.03–1.35], p = 0.02) and current anxiety disorder (aOR = 6.18 [2.15–17.75], p = 0.001), independently of age and gender. No association of hypovitaminosis D with respectively positive and negative symptoms, cognitive scores or other biological variables has been found (all p > 0.05), however, a trend toward significance has been found for metabolic syndrome (p = 0.06). Vitamin D supplementation has been administered during the previous 12 months in only 8.5% of the subjects but was associated with lower depressive symptoms (aOR = 0.67 [0.46–0.98], p = 0.04) and lower rate of current anxiety disorder (aOR = 0.06 [0.01–0.66], p = 0.02) compared to patients with hypovitaminosis D. Conclusion Hypovitaminosis D is frequent and associated with depressive symptoms and anxiety disorders in schizophrenia. Vitamin D supplementation is associated with lower depressive and anxiety symptoms, however patients with hypovitaminosis D remain insufficiently treated.
Keywords : Anxiety Depression Schizophrenia Vitamin D Metabolic syndrome
Document type :
Journal articles
Complete list of metadata

Cited literature [53 references]  Display  Hide  Download
https://hal-amu.archives-ouvertes.fr/hal-02473628
Contributor : Guillaume Fond <>
Submitted on : Monday, February 10, 2020 - 6:54:57 PM
Last modification on : Saturday, July 31, 2021 - 3:27:43 AM
Long-term archiving on: : Monday, May 11, 2020 - 5:04:32 PM

Files

Vignette du document
4 FACE VITDlb.pdf
Files produced by the author(s)

Identifiers

Collections

UNIV-AMU | IMRB | UPEC-UPEM | UPEC | UVSQ | ACL-SVSAE | UNIV-ST-ETIENNE | UNIV-LYON1 | IPLESP | NPSY-SYDO | SITE-ALSACE | SORBONNE-UNIVERSITE | UNIV-PARIS7 | SU-MEDECINE | CNRS | UDL | PRES_CLERMONT | USPC | UNIV-PARIS | SU-TI

Citation

Guillaume Fond, O. Godin, F. Schürhoff, F. Berna, E. Bulzacka, et al.. Hypovitaminosis D is associated with depression and anxiety in schizophrenia: results from the national FACE-SZ cohort. Running title: hypovitaminosis D, depression and anxiety in schizophrenia. Psychiatry Research, Elsevier, 2018, 270, pp.104-110. ⟨10.1016/j.psychres.2018.09.024⟩. ⟨hal-02473628⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

386

Files downloads

913